过氧化氢酶对镉敏感型和镉耐受型金黄色葡萄球菌中镉毒性的影响。
The effect of catalase on the toxicity of cadmium in cadmium-sensitive and cadmium-resistant Staphylococcus aureus.
作者信息
Korkeala H, Sankari S
出版信息
Acta Vet Scand. 1980;21(2):209-23. doi: 10.1186/BF03546884.
The effect of catalase on the toxicity of cadmium (Cd) in Cd-resistant Staphylococcus aureus 3719+ and its plasmid-negative Cd-sensitive variant 3719– was studied. Catalase on a solid medium increased the recovery of Gd-stressed S. aureus 3719– cells, and the addition of catalase into a liquid growth medium resulted in a shortened lag phase of growth especially in S. aureus 3719–. The catalase activity of S. aureus 3719+ cell suspensions was greater than the corresponding activity of S. aureus 3719– cell suspensions. Cd did not influence the activity of beef liver catalase or the catalase production of the bacterial cells. Catalase reduced the toxicity of Cd especially for S. aureus 3719–. The greater catalase production of S. aureus 3719+ might be one factor in its resistance against the toxic effects of Cd. It is suggested that Cd together with hydrogen peroxide may induce oxidative damage to cells if there is not sufficient catalase available to decompose all the hydrogen peroxide formed.
研究了过氧化氢酶对耐镉金黄色葡萄球菌3719+及其质粒阴性的镉敏感变体3719–中镉（Cd）毒性的影响。固体培养基上的过氧化氢酶提高了受镉胁迫的金黄色葡萄球菌3719–细胞的存活率，向液体生长培养基中添加过氧化氢酶导致生长延迟期缩短，尤其是在金黄色葡萄球菌3719–中。金黄色葡萄球菌3719+细胞悬液的过氧化氢酶活性高于金黄色葡萄球菌3719–细胞悬液的相应活性。镉不影响牛肝过氧化氢酶的活性或细菌细胞的过氧化氢酶产生。过氧化氢酶降低了镉的毒性，尤其是对金黄色葡萄球菌3719–。金黄色葡萄球菌3719+产生更多的过氧化氢酶可能是其对镉毒性具有抗性的一个因素。研究表明，如果没有足够的过氧化氢酶来分解所有生成的过氧化氢，镉与过氧化氢可能会诱导细胞发生氧化损伤。
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