脂肪酸对多烯抗生素作用的影响。
Effect of fatty acids on action of polyene antibiotics.
作者信息
Iannitelli R C, Ikawa M
出版信息
Antimicrob Agents Chemother. 1980 May;17(5):861-4. doi: 10.1128/AAC.17.5.861.
Abstract
Fatty acids cause a decrease in the absorption spectra of the antifungal polyene macrolide antibiotics nystatin, filipin, candicidin, and amphotericin B. For nystatin, filipin, and candicidin, this decrease in absorption could be correlated with the activity of the fatty acids in protecting the yeast Saccharomyces cerevisiae against the action of these antibiotics. With amphotericin B a correlation was observed between the decrease in absorption caused by certain derivatives of fatty acids and the protective action of these derivatives against the activity of amphotericin B on yeast. It is concluded that, like the sterols, fatty acids also interact with the polyene antibiotics and thereby reduce their effective concentrations.
摘要
脂肪酸会导致抗真菌多烯大环内酯类抗生素制霉菌素、菲律宾菌素、杀假丝菌素和两性霉素B的吸收光谱降低。对于制霉菌素、菲律宾菌素和杀假丝菌素，这种吸收降低与脂肪酸保护酿酒酵母免受这些抗生素作用的活性相关。对于两性霉素B，观察到某些脂肪酸衍生物引起的吸收降低与这些衍生物对两性霉素B在酵母上活性的保护作用之间存在相关性。得出的结论是，与固醇一样，脂肪酸也与多烯抗生素相互作用，从而降低其有效浓度。
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本文引用的文献
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