Curreri P W, Desai M H, Bartlett R H, Heimbach D M, Parshley P, Trunkey D
Arch Surg. 1980 Aug;115(8):925-7. doi: 10.1001/archsurg.1980.01380080021004.
A three-tiered, multicenter study evaluated the safety and efficacy of a new synthetic dressing for burn injuries. The first tier compared use of the test dressing with use of a conventional topical chemotherapeutic agent; the test dressing afforded greater patient comfort, equivalent control of bacterial growth, less frequent dressing change, and possibly faster reepithelialization. Drawbacks included difficulty of application, poor adherence during the first 24 hours after injury, frequent necessity to repair cracks and fissures, and inability to easily monitor burn wounds for bacterial growth. Subsequent tiers were noncomparative but included patients with more severe injuries. The test dressing may be useful in treating superficial and moderate second-degree burns of less than 20% of the total body surface area and possibly in treating iatrogenic "burn" wounds such as donor sites. Its use on third-degree burns is not recommended.
一项三级多中心研究评估了一种新型烧伤合成敷料的安全性和有效性。第一阶段将测试敷料的使用与传统局部化疗药物的使用进行了比较；测试敷料能为患者带来更大的舒适度，对细菌生长的控制效果相当，换药频率更低，且可能使上皮再形成速度更快。缺点包括应用困难、受伤后24小时内粘附性差、频繁需要修复裂缝，以及难以轻松监测烧伤创面的细菌生长情况。后续阶段不具有可比性，但纳入了伤势更严重的患者。该测试敷料可能有助于治疗体表面积小于20%的浅度和中度二度烧伤，也可能有助于治疗医源性“烧伤”创面，如供皮区。不建议将其用于三度烧伤。
