Fang C H, Nathan P, Robb E C, Alexander J W, MacMillan B G
J Burn Care Rehabil. 1987 May-Jun;8(3):206-9. doi: 10.1097/00004630-198705000-00006.
This clinical trial prospectively evaluates the potential beneficial effects of antimicrobial drug delivery from a synthetic dressing (Hydron-AgSD) formed on second-degree burn wounds. A paste composed of polyethylene glycol-400, poly 2-OH ethylmethacrylate, and silver sulfadiazine (AgSD 1%-3%) matured within one hour to form a solid dressing. In 27 patients, comparable areas of second-degree wounds on the same patient were selected at random for test and control (silver sulfadiazine 1% only) sites. The mean total time of the synthetic dressing application per patient was about nine days, and each dressing remained in place for nearly four days. During this interval the control sites required four dressings changes. In 17 tests for infections, the control areas were contaminated but no bacteria were detected under the synthetic dressing; in three tests, the controls had no bacteria, whereas the synthetic dressing did. Healing of burns was similar under both types of dressing. Benefits of Hydron treatment included increased patient comfort because of the reduced number of dressing changes and, in some cases, greater freedom from contaminating bacteria.
这项临床试验前瞻性地评估了由形成于二度烧伤创面的合成敷料（Hydron-AgSD）进行抗菌药物递送的潜在有益效果。一种由聚乙二醇-400、聚甲基丙烯酸2-羟乙酯和磺胺嘧啶银（1%-3%的AgSD）组成的糊剂在一小时内成熟形成固体敷料。在27例患者中，随机选择同一患者身上可比面积的二度创面作为试验部位和对照部位（仅1%的磺胺嘧啶银）。每位患者应用合成敷料的平均总时间约为九天，每次敷料留置近四天。在此期间，对照部位需要更换四次敷料。在17次感染检测中，对照区域被污染，但在合成敷料下未检测到细菌；在三次检测中，对照部位没有细菌，而合成敷料下有细菌。两种类型的敷料下烧伤愈合情况相似。Hydron治疗的益处包括因减少敷料更换次数而提高了患者舒适度，并且在某些情况下，减少了细菌污染。
