胍法辛对警觉性的影响。
Effect of guanfacine on vigilance.
作者信息
Heidbreder E, Pagel G, Roeckel A, Heidland A
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):169S-172S. doi: 10.1111/j.1365-2125.1980.tb04926.x.
Abstract
- In 20 patients suffering from mild hypertension (WHO classification I-II) the effect on vigilance was studied under double-blind conditions. Ten patients were given guanfacine 2 mg daily and ten others a placebo preparation. 2. Before the study and following 2 weeks' medication a battery of tests was applied in which the reaction time and attention were subjected to comparative analysis. The variation in blood pressure and heart rate under mental stress conditions was also tested. 3. The study shows a non-significant reduction in blood pressure in the guanfacine group without the parameters of vigilance being affected. Under mental stress, there was no impairment of haemodynamic reactions. 4. It is concluded that guanfacine, at the selected dose of 2 mg daily, has no apparent effect on the vigilance of hypertensive patients.
摘要
- 对20例轻度高血压患者（世界卫生组织分类I-II级）在双盲条件下研究了其对警觉性的影响。10例患者每日服用2毫克胍法辛，另外10例服用安慰剂制剂。2. 在研究前和用药2周后进行了一系列测试，对反应时间和注意力进行了对比分析。还测试了精神应激状态下血压和心率的变化。3. 研究表明，胍法辛组血压有不显著降低，而警觉性参数未受影响。在精神应激状态下，血流动力学反应未受损。4. 得出结论，每日选定剂量2毫克的胍法辛对高血压患者的警觉性无明显影响。
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