可乐定撤药的影响：可能机制及处理建议
Effects of clonidine withdrawal: possible mechanisms and suggestions for management.
作者信息
Hunyor S N, Hansson L, Harrison T S, Hoobler S W
出版信息
Br Med J. 1973 Apr 28;2(5860):209-11. doi: 10.1136/bmj.2.5860.209.
Abstract
A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The blood pressure can be controlled and the symptoms alleviated promptly by alpha and beta adrenergic receptor blockade using intravenous phentolamine and propranolol.
摘要
有5例患者在先前停用可乐定（Catapres）时出现血压严重反跳性升高，并伴有激动和失眠。已证实这种情况在这些患者中可重现，且与尿儿茶酚胺排泄显著增加有关。使用静脉注射酚妥拉明和普萘洛尔进行α和β肾上腺素能受体阻滞，可迅速控制血压并缓解症状。
相似文献
1
Effects of clonidine withdrawal: possible mechanisms and suggestions for management.
Br Med J. 1973 Apr 28;2(5860):209-11. doi: 10.1136/bmj.2.5860.209.
2
Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management.
Am Heart J. 1973 May;85(5):605-10. doi: 10.1016/0002-8703(73)90165-8.
3
Blood pressure over-shoot due to acute clonidine (Catapres) withdrawal: studies on arterial and urinary catecholamines and suggestions for management of the crisis.
Clin Sci Mol Med Suppl. 1973 Aug;45 Suppl 1:181s-3. doi: 10.1042/cs045181s.
4
Clonidine withdrawal in hypertension. Changes in blood-pressure and plasma and urinary noradrenaline.
Lancet. 1977 Jun 4;1(8023):1171-4. doi: 10.1016/s0140-6736(77)92715-5.
5
Clonidine withdrawal. Mechanism and frequency of rebound hypertension.
Br J Clin Pharmacol. 1979 Jan;7(1):55-62. doi: 10.1111/j.1365-2125.1979.tb00897.x.
6
Evaluation of clonidine hydrochloride (Catapres). A new antihypertensive agent.
JAMA. 1975 Jul 14;233(2):174-6.
7
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
Trials. 2012 Sep 26;13:177. doi: 10.1186/1745-6215-13-177.
8
Rebound phenomena in Tourette's syndrome after abrupt withdrawal of clonidine. Behavioral, cardiovascular, and neurochemical effects.
Arch Gen Psychiatry. 1986 Dec;43(12):1168-76. doi: 10.1001/archpsyc.1986.01800120054011.
9
Regimen for the control of blood pressure and symptoms during clonidine withdrawal.
Int J Clin Pharmacol Res. 1985;5(4):215-22.
10
Withdrawal phenomena in subjects with essential hypertension on clonidine or tiamenidine.
Clin Pharmacol Ther. 1984 Nov;36(5):628-33. doi: 10.1038/clpt.1984.232.
引用本文的文献
1
Clonidine use during dexmedetomidine weaning: A systematic review.
World J Crit Care Med. 2023 Jan 9;12(1):18-28. doi: 10.5492/wjccm.v12.i1.18.
2
The effect of a topical combination of clonidine and pentoxifylline on post-traumatic neuropathic pain patients: study protocol for a randomized, double-blind placebo-controlled trial.
Trials. 2021 Feb 17;22(1):149. doi: 10.1186/s13063-021-05088-w.
3
Clonidine withdrawal induced sympathetic surge.
BMJ Case Rep. 2015 Jun 2;2015:bcr2015210325. doi: 10.1136/bcr-2015-210325.
4
Problems with Beta Adrenergic Blocking Drugs and other Antihypertensive Drugs.
Proc R Soc Med. 1977;70(Suppl 5):40-4. doi: 10.1177/00359157770700S518.
5
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Dec;348(6):601-7. doi: 10.1007/BF00167236.
6
The Fourth Lilly Prize Lecture, University of Aberdeen, September 1980. The clinical pharmacology of clonidine and related central antihypertensive agents.
Br J Clin Pharmacol. 1981 Sep;12(3):295-302. doi: 10.1111/j.1365-2125.1981.tb01217.x.
7
Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension.
Eur J Clin Pharmacol. 1981;19(5):309-15. doi: 10.1007/BF00544579.
8
Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline.
Eur J Clin Pharmacol. 1981 Jan;19(1):19-24. doi: 10.1007/BF00558376.
9
Comparison of guanfacine and clonidine as antihypertensive agents.
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):67S-70S. doi: 10.1111/j.1365-2125.1980.tb04908.x.
10
Guanfacine: effects of long-term treatment and withdrawal.
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):183S-188S. doi: 10.1111/j.1365-2125.1980.tb04928.x.
本文引用的文献
1
EFFECTS OF SMALL ORAL DOSES OF RESERPINE ON VASCULAR RESPONSES TO TYRAMINE AND NOREPINEPHRINE IN MAN.
Circulation. 1964 Feb;29:219-23. doi: 10.1161/01.cir.29.2.219.
2
Improved technique for the fluorimetric estimation of catecholamines.
Acta Physiol Scand. 1961 Apr;51:348-55. doi: 10.1111/j.1748-1716.1961.tb02128.x.
3
Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride.
Am Heart J. 1969 Apr;77(4):473-8. doi: 10.1016/0002-8703(69)90156-2.
4
Antihypertensive effect of a new imidazoline compound (clonidine) and chlorthalidone, individually and in combination.
Am J Cardiol. 1970 Sep;26(3):258-61. doi: 10.1016/0002-9149(70)90792-7.
5
Studies on catecholamines, renin and aldosterone following Catapresan (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients.
Eur J Pharmacol. 1970;10(3):389-97. doi: 10.1016/0014-2999(70)90212-8.
6
The use of "Catapres" in the treatment of severe hypertension.
Med J Aust. 1969 Oct 4;2(14):684-7. doi: 10.5694/j.1326-5377.1969.tb107345.x.
7
Comparison of clonidine and methyldopa on blood pressure and side effects in hypertensive patients.
Am Heart J. 1972 Apr;83(4):464-8. doi: 10.1016/0002-8703(72)90036-1.
Zotero 插件