Quinn P J, Chapman D
CRC Crit Rev Biochem. 1980;8(1):1-117. doi: 10.3109/10409238009105466.
The membranes of living organisms are involved in many aspects of the life, growth and development of all cells. The predominant structural elements of these membranes are lipids and proteins and the basic strucvture of these molecules has been reviewed. The physical properties of the lipid constituents particularly their behavior in aqueous systems has led to the concepts of thermotropic and lyotropic mesomorphism; the interaction between different types of lipid molecules modulate this behavior. Interaction of phospholipids in aqueous systems with cholesterol, ions and drugs have been examined in this context. In addition a variety of model lipid-protein systems have been investigated and the implications of interactions between lipids and different proteins in biological membranes has been evaluated. This leads to a detailed consideration of the way lipids and proteins ae organized in cell membranes and contains an appraisal of the evidence supporting contemporary views of membrane structure. Particular attention has been devoted to the question of how mobile the components are within the structure. Particular attention has been devoted to the question of how mobile the components are within the structure. Finally the biosynthesis, turnover and modulation of the properties of interacting membrane constituents is critically reviewed and possible ways of controlling the behavior of cells and organisms by altering the structural parameters of different membranes has been considered.
生物膜参与了所有细胞生命、生长和发育的许多方面。这些膜的主要结构成分是脂质和蛋白质，并且这些分子的基本结构已被综述。脂质成分的物理性质，特别是它们在水性体系中的行为，引出了热致和溶致液晶态的概念；不同类型脂质分子之间的相互作用调节了这种行为。在此背景下，已经研究了水性体系中磷脂与胆固醇、离子和药物之间的相互作用。此外，还研究了各种模型脂质 - 蛋白质体系，并评估了脂质与生物膜中不同蛋白质之间相互作用的影响。这导致了对脂质和蛋白质在细胞膜中组织方式的详细思考，并包含了对支持当代膜结构观点的证据的评估。特别关注了组分在结构内的移动性问题。最后，对相互作用的膜成分的生物合成、周转和性质调节进行了批判性综述，并考虑了通过改变不同膜的结构参数来控制细胞和生物体行为的可能方法。
