血清白蛋白的脂肪酸结合位点作为链球菌脂磷壁酸的膜受体类似物。
Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid.
作者信息
Simpson W A, Ofek I, Beachey E H
出版信息
Infect Immun. 1980 Jul;29(1):119-22. doi: 10.1128/iai.29.1.119-122.1980.
Abstract
The ability of bovine serum albumin to inhibit the binding of group A streptococcal lipoteichoic acid (LTA) to human cells was investigated. Albumin blocked the ability of LTA to sensitize erythrocytes to agglutinate in the presence of anti-LTA in a dose-dependent manner. The inhibition of LTA binding to erythrocytes was demonstrated directly with radiolabeled LTA. At an albumin/LTA molar ratio of 1.5:1, albumin binding of the radiolabeled LTA at erythrocytes was inhibited by 45%. Analysis of the binding of radiolabeled LTA to erythrocytes in the presence of albumin indicated that albumin competitively inhibited the binding of LTA to putative cell membrane receptors, indicating that albumin and erythrocytes both bind to the same moiety on the LTA molecule.
摘要
研究了牛血清白蛋白抑制A组链球菌脂磷壁酸（LTA）与人细胞结合的能力。白蛋白以剂量依赖的方式阻断了LTA在抗LTA存在下使红细胞致敏凝集的能力。用放射性标记的LTA直接证明了LTA与红细胞结合的抑制作用。在白蛋白/LTA摩尔比为1.5:1时，红细胞上放射性标记的LTA的白蛋白结合被抑制了45%。在白蛋白存在下对放射性标记的LTA与红细胞结合的分析表明，白蛋白竞争性抑制LTA与假定细胞膜受体的结合，这表明白蛋白和红细胞都与LTA分子上的同一部分结合。
相似文献
1
Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid.血清白蛋白的脂肪酸结合位点作为链球菌脂磷壁酸的膜受体类似物。
Infect Immun. 1980 Jul;29(1):119-22. doi: 10.1128/iai.29.1.119-122.1980.
2
Erythrocyte binding properties of streptococcal lipoteichoic acids.链球菌脂磷壁酸的红细胞结合特性
Infect Immun. 1979 Mar;23(3):618-25. doi: 10.1128/iai.23.3.618-625.1979.
3
Characteristics of the binding of streptococcal lipoteichoic acid to human oral epithelial cells.链球菌脂磷壁酸与人口腔上皮细胞结合的特性
J Infect Dis. 1980 Apr;141(4):457-62. doi: 10.1093/infdis/141.4.457.
4
Formation of molecular complexes between a structurally defined M protein and acylated or deacylated lipoteichoic acid of Streptococcus pyogenes.化脓性链球菌结构明确的M蛋白与酰化或去酰化脂磷壁酸之间分子复合物的形成。
J Bacteriol. 1982 Feb;149(2):426-33. doi: 10.1128/jb.149.2.426-433.1982.
5
Binding of lipoteichoic acid of group A streptococci to isolated human erythrocyte membranes.A组链球菌的脂磷壁酸与分离的人红细胞膜的结合。
Infect Immun. 1979 Oct;26(1):316-21. doi: 10.1128/iai.26.1.316-321.1979.
6
Binding of streptococcal lipoteichoic acid to fatty acid-binding sites on human plasma fibronectin.链球菌脂磷壁酸与人血浆纤连蛋白上脂肪酸结合位点的结合。
J Bacteriol. 1983 Feb;153(2):763-70. doi: 10.1128/jb.153.2.763-770.1983.
7
Characterization of lipoteichoic acid binding to polymorphonuclear leukocytes of human blood.脂磷壁酸与人血多形核白细胞结合的特性分析。
Infect Immun. 1981 May;32(2):625-31. doi: 10.1128/iai.32.2.625-631.1981.
8
Blood-group-reactive glycoprotein from human saliva interacts with lipoteichoic acid on the surface of Streptococcus sanguis cells.人唾液中的血型反应性糖蛋白与血链球菌细胞表面的脂磷壁酸相互作用。
Arch Oral Biol. 1982;27(3):261-8. doi: 10.1016/0003-9969(82)90060-7.
9
Release of fibronectin-lipoteichoic acid complexes from group A streptococci with penicillin.用青霉素从A组链球菌中释放纤连蛋白-脂磷壁酸复合物
Infect Immun. 1986 Feb;51(2):529-35. doi: 10.1128/iai.51.2.529-535.1986.
10
The binding of Pneumococcal lipoteichoic acid to human erythrocytes.肺炎球菌脂磷壁酸与人红细胞的结合。
Microb Pathog. 1993 Jan;14(1):23-31. doi: 10.1006/mpat.1993.1003.
引用本文的文献
1
Seventy-Five Years of Research on Protein Binding.七十五年来的蛋白质结合研究。
Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01663-17. Print 2018 Feb.
2
Novel role for albumin in innate immunity: serum albumin inhibits the growth of Blastomyces dermatitidis yeast form in vitro.白蛋白在固有免疫中的新作用：血清白蛋白在体外抑制皮炎芽生菌酵母型的生长。
Infect Immun. 2003 Nov;71(11):6648-52. doi: 10.1128/IAI.71.11.6648-6652.2003.
3
Surfactant protein D enhances phagocytosis and killing of unencapsulated phase variants of Klebsiella pneumoniae.表面活性蛋白D增强了对肺炎克雷伯菌非荚膜相变体的吞噬作用和杀伤能力。
Infect Immun. 2001 Jan;69(1):24-33. doi: 10.1128/IAI.69.1.24-33.2001.
4
M protein mediates streptococcal adhesion to HEp-2 cells.M蛋白介导链球菌对人喉表皮样癌细胞（HEp-2细胞）的黏附。
Infect Immun. 1994 Feb;62(2):442-8. doi: 10.1128/iai.62.2.442-448.1994.
5
The adherence of group A streptococci to oropharyngeal cells: the lipoteichoic acid adhesin and fibronectin receptor.A组链球菌对口咽细胞的黏附：脂磷壁酸黏附素和纤连蛋白受体
Infection. 1982;10(2):107-11. doi: 10.1007/BF01816738.
6
Formation of molecular complexes between a structurally defined M protein and acylated or deacylated lipoteichoic acid of Streptococcus pyogenes.化脓性链球菌结构明确的M蛋白与酰化或去酰化脂磷壁酸之间分子复合物的形成。
J Bacteriol. 1982 Feb;149(2):426-33. doi: 10.1128/jb.149.2.426-433.1982.
7
Effect of estrogens on bacterial adherence to HeLa cells.雌激素对细菌黏附于宫颈癌细胞的影响。
Infect Immun. 1982 Feb;35(2):633-8. doi: 10.1128/iai.35.2.633-638.1982.
8
Characterization of lipoteichoic acid binding to polymorphonuclear leukocytes of human blood.脂磷壁酸与人血多形核白细胞结合的特性分析。
Infect Immun. 1981 May;32(2):625-31. doi: 10.1128/iai.32.2.625-631.1981.
9
In vitro adherence of bacteria to prosthetic vascular grafts.细菌在体外对人工血管移植物的黏附。
Infection. 1982 Jan;10(1):9-14. doi: 10.1007/BF01640828.
10
Receptor in group C and G streptococci detects albumin structures present in mammalian species.C组和G组链球菌中的受体可检测哺乳动物物种中存在的白蛋白结构。
Infect Immun. 1982 May;36(2):469-75. doi: 10.1128/iai.36.2.469-475.1982.
本文引用的文献
1
The interaction of human erythrocytes with sodium palmitate.人红细胞与棕榈酸钠的相互作用。
J Clin Invest. 1958 Dec;37(12):1729-35. doi: 10.1172/JCI103765.
2
Immunological properties of teichoic acids.磷壁酸的免疫学特性。
Bacteriol Rev. 1973 Jun;37(2):215-57. doi: 10.1128/br.37.2.215-257.1973.
3
Membrane lipoteichoic acid of Streptococcus pyogenes and its stabilized L-form and the effect of two antibiotics upon its cellular content.化脓性链球菌的膜脂磷壁酸及其稳定的L型以及两种抗生素对其细胞成分的影响。
J Bacteriol. 1976 Aug;127(2):855-62. doi: 10.1128/jb.127.2.855-862.1976.
4
Epithelial cell binding of group A streptococci by lipoteichoic acid on fimbriae denuded of M protein.脂磷壁酸介导A组链球菌与去除M蛋白的菌毛上皮细胞结合。
J Exp Med. 1976 Apr 1;143(4):759-71. doi: 10.1084/jem.143.4.759.
5
Purification of lipoteichoic acids by using phosphatidyl choline vesicles.利用磷脂酰胆碱囊泡纯化脂磷壁酸。
Infect Immun. 1978 Oct;22(1):107-18. doi: 10.1128/iai.22.1.107-118.1978.
6
Binding of lipoteichoic acid of group A streptococci to isolated human erythrocyte membranes.A组链球菌的脂磷壁酸与分离的人红细胞膜的结合。
Infect Immun. 1979 Oct;26(1):316-21. doi: 10.1128/iai.26.1.316-321.1979.
7
Erythrocyte binding properties of streptococcal lipoteichoic acids.链球菌脂磷壁酸的红细胞结合特性
Infect Immun. 1979 Mar;23(3):618-25. doi: 10.1128/iai.23.3.618-625.1979.
8
Lymphocytes binding and T cell mitogenic properties of group A streptococcal lipoteichoic acid.A组链球菌脂磷壁酸的淋巴细胞结合及T细胞促有丝分裂特性
J Immunol. 1979 Jan;122(1):189-95.
9
Excretion of lipoteichoic acid by group A streptococci. Influence of penicillin on excretion and loss of ability to adhere to human oral mucosal cells.A 组链球菌脂磷壁酸的排泄。青霉素对排泄及黏附人口腔黏膜细胞能力丧失的影响。
J Clin Invest. 1978 Mar;61(3):671-7. doi: 10.1172/JCI108979.
10
Interaction of lipoteichoic acid of group A streptococci with human platelets.A组链球菌脂磷壁酸与人血小板的相互作用。
Infect Immun. 1977 May;16(2):649-54. doi: 10.1128/iai.16.2.649-654.1977.
Zotero 插件