Simpson W A, Ofek I, Beachey E H
Infect Immun. 1980 Jul;29(1):119-22. doi: 10.1128/iai.29.1.119-122.1980.
The ability of bovine serum albumin to inhibit the binding of group A streptococcal lipoteichoic acid (LTA) to human cells was investigated. Albumin blocked the ability of LTA to sensitize erythrocytes to agglutinate in the presence of anti-LTA in a dose-dependent manner. The inhibition of LTA binding to erythrocytes was demonstrated directly with radiolabeled LTA. At an albumin/LTA molar ratio of 1.5:1, albumin binding of the radiolabeled LTA at erythrocytes was inhibited by 45%. Analysis of the binding of radiolabeled LTA to erythrocytes in the presence of albumin indicated that albumin competitively inhibited the binding of LTA to putative cell membrane receptors, indicating that albumin and erythrocytes both bind to the same moiety on the LTA molecule.
研究了牛血清白蛋白抑制A组链球菌脂磷壁酸（LTA）与人细胞结合的能力。白蛋白以剂量依赖的方式阻断了LTA在抗LTA存在下使红细胞致敏凝集的能力。用放射性标记的LTA直接证明了LTA与红细胞结合的抑制作用。在白蛋白/LTA摩尔比为1.5:1时，红细胞上放射性标记的LTA的白蛋白结合被抑制了45%。在白蛋白存在下对放射性标记的LTA与红细胞结合的分析表明，白蛋白竞争性抑制LTA与假定细胞膜受体的结合，这表明白蛋白和红细胞都与LTA分子上的同一部分结合。
