Widebäck K, Seal U S, Kronvall G
Infect Immun. 1982 May;36(2):469-75. doi: 10.1128/iai.36.2.469-475.1982.
The presence of albumin structures with the capacity to bind to a surface receptor in group C and G streptococci was studied in serum samples from 45 mammalian species representing 15 different orders, using an inhibition assay. The ability of animal sera to inhibit the uptake of radiolabeled human serum albumin by the streptococci indicated the presence of such albumin structures. Positive reactions were found in species of most orders tested, with Marsupialia as a notable exception. All Carnivora sera tested were strongly positive. In some orders such as Artiodactyla both positive and negative species were identified. Serum samples from 62 bird species representing 15 orders and from 5 fish species were also tested in the inhibition assay. None of these serum samples was capable of inhibiting the uptake of human serum albumin by streptococci. Some differences were also noted in the results obtained with group C and G streptococci from human and bovine sources, respectively, indicating the presence of two types of receptors. The present studies suggest a phylogenetic origin of albumin structures with affinity for the streptococcal receptor to a period after the divergence of Marsupialia from the other mammalian orders.
利用抑制试验，对来自代表15个不同目、45种哺乳动物的血清样本中C组和G组链球菌中具有与表面受体结合能力的白蛋白结构进行了研究。动物血清抑制链球菌摄取放射性标记的人血清白蛋白的能力表明存在此类白蛋白结构。在大多数受试目的物种中都发现了阳性反应，有袋目是一个显著例外。所有受试的食肉目动物血清均呈强阳性。在某些目，如偶蹄目，同时鉴定出了阳性和阴性物种。还对来自代表15个目的62种鸟类和5种鱼类的血清样本进行了抑制试验。这些血清样本均不能抑制链球菌摄取人血清白蛋白。分别用人源和牛源的C组和G组链球菌进行试验，结果也存在一些差异，表明存在两种类型的受体。目前的研究表明，与链球菌受体具有亲和力的白蛋白结构的系统发育起源可追溯到有袋目与其他哺乳动物目分化之后的时期。
