Hehrmann R, Tidow G, Offner G, Krohn H P, Hesch R D, Pichlmayr R
Klin Wochenschr. 1980 Mar 3;58(5):249-58. doi: 10.1007/BF01476971.
Patients after kidney transplantation were investigated for parameters for kidney function and calcium metabolism including a definitively characterized parathyroid hormone (PTH) radioimmunoassay, of which quality criteria have been documented. In 72 transplanted patients 3 months to 7 years after operation a close correlation between graft function and plasma PTH concentrations was found. Patients with clearly elevated PTH revealed definitively decreased graft function. Three patients with normal GFR and clearly elevated PTH showed - at least transiently - all criteria of an autonomous hyperparathyroidism including hypercalcaemia and hypophosphataemia. Borderline PTH elevations associated with normal GFR can be explained by corticosteroid treatment. In 100 patients, which were investigated before and during the first 10 days after transplantation, again a close correlation was documented between the development of PTH concentrations and the function of the transplanted kidney. PTH concentrations are not only a very sensitive parameter of graft function; in various situations plasma PTH concentrations additionally allow an estimate of graft prognosis. This is particularly true in primary graft failure and in early rejection episodes.
对肾移植后的患者进行了肾功能和钙代谢参数的研究，包括一种特征明确的甲状旁腺激素（PTH）放射免疫测定法，其质量标准已有文献记载。在72例术后3个月至7年的移植患者中，发现移植肾功能与血浆PTH浓度之间存在密切相关性。PTH明显升高的患者移植肾功能明显下降。3例肾小球滤过率（GFR）正常但PTH明显升高的患者至少短暂出现了自主性甲状旁腺功能亢进的所有标准，包括高钙血症和低磷血症。GFR正常但PTH轻度升高可由皮质类固醇治疗解释。在100例移植前及移植后前10天内接受调查的患者中，再次证明PTH浓度的变化与移植肾功能之间存在密切相关性。PTH浓度不仅是移植肾功能的一个非常敏感的参数；在各种情况下，血浆PTH浓度还可以评估移植预后。在原发性移植失败和早期排斥反应中尤其如此。
