Zavala D C, Rhodes M L
Chest. 1978 Oct;74(4):418-20. doi: 10.1378/chest.74.4.418.
Thirty-six rabbits received the herbicide, paraquat (1,1'-dimethyl-4,4'-dipyridylium dichloride), by selective intrabronchial instillation in doses ranging from 0.1 gm to 1 pg. Sixteen additional rabbits were given paraquat dichloride (25 mg/kg of body weight) intraperitoneally, subcutaneously, intravenously, or orally. The lung of the rabbit proved to be highly sensitive to paraquat administered by intrabronchial deposition, moderately sensitive to intravenously administered paraquat, and resistant to the chemical when given intraperitoneally or subcutaneously. One picogram of paraquat dichloride delivered by bronchial catheter produced a 1.0-mm pulmonary lesion consisting of focal hemorrhage, congestion of capillaries, intra-alveolar macrophages, and moderate thickening of the alveolar septa. This finding suggests that pulmonary damage could potentially result from smoking marihuana that has been sprayed with paraquat.
36只兔子通过选择性支气管内滴注接受了除草剂百草枯（1,1'-二甲基-4,4'-联吡啶二氯化物），剂量范围为0.1克至1皮克。另外16只兔子通过腹腔内、皮下、静脉内或口服给予百草枯二氯化物（25毫克/千克体重）。事实证明，兔子的肺对通过支气管内沉积给予的百草枯高度敏感，对静脉内给予的百草枯中度敏感，而对腹腔内或皮下给予的这种化学物质具有抗性。通过支气管导管输送1皮克百草枯二氯化物会产生一个1.0毫米的肺部病变，包括局部出血、毛细血管充血、肺泡巨噬细胞以及肺泡间隔中度增厚。这一发现表明，吸食喷洒了百草枯的大麻可能会对肺部造成损害。
