Kokubo T, Takahashi M, Furukawa F, Nagano K, Hayashi Y
Acta Pathol Jpn. 1984 Jan;34(1):41-6. doi: 10.1111/j.1440-1827.1984.tb02180.x.
Three dimensional reconstructions of pulmonary arteries and the bronchial tree were made to evaluate the cause of hemorrhage in the lungs of hamsters treated with a single intraperitoneal injection of paraquat at a dose of 15 mg/kg b.w. The hemorrhage corresponding to the respiratory bronchiolar segment formed the minimum hemorrhagic unit; larger hemorrhages were composed of conglomerations of such units. The respiratory bronchiolar segment was fed by a single respiratory bronchiolar arteriole which had a distinct muscular medial coat. No evidence of breakage of the arterial wall passing through the hemorrhagic lesion could be detected even by careful observation with serial histological sections. Accordingly, the cause of the lung hemorrhage was sought in the combined effects of paraquat toxicity to the capillary endothelium and vasoconstriction of the respiratory bronchiolar arterioles.
对接受单次腹腔注射剂量为15毫克/千克体重百草枯处理的仓鼠肺部进行肺动脉和支气管树的三维重建，以评估肺部出血的原因。与呼吸性细支气管段相对应的出血形成了最小出血单位；较大的出血是由这些单位的聚集组成的。呼吸性细支气管段由一条具有明显肌性中膜的单一呼吸性细支气管小动脉供血。即使通过连续组织切片仔细观察，也未发现穿过出血病变的动脉壁有破裂迹象。因此，肺部出血的原因在于百草枯对毛细血管内皮的毒性作用与呼吸性细支气管小动脉血管收缩的联合效应。
