Michel J, Miller J, Sacks T
Chemotherapy. 1980;26(6):427-30. doi: 10.1159/000237938.
The virulence of a multiple antibiotic-resistant isolate of Escherichia coli was compared to that of the same isolate 'cured' of its resistance by acridine orange, and to that of the cured bacteria transformed back to resistance by the plasmid DNA extracted from the original resistant isolate. There were virtually no differences in the mouse LD 50 of these three variants of the same organism.
将一株多重耐药性大肠杆菌分离株的毒力，与用吖啶橙使其耐药性“治愈”后的同一分离株，以及用从原始耐药分离株中提取的质粒DNA转化回耐药性的“治愈”细菌的毒力进行了比较。同一生物体的这三种变体在小鼠半数致死剂量方面几乎没有差异。
