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旋毛虫病:流行病学、临床特征与诊断(作者译)

[Trichinosis: epidemiology, clinical features and diagnosis (author's transl)].

作者信息

Stumpf J, Kaduk B, Undeutsch K, Landgraf H, Gofferje H

出版信息

Dtsch Med Wochenschr. 1978 Oct 6;103(40):1556-8, 1561-2. doi: 10.1055/s-0028-1129300.

DOI:10.1055/s-0028-1129300
PMID:699765
Abstract

After ingestion of wild boar meat 58 patients developed typical clinical signs and symptoms of trichinosis. All patients had marked blood eosinophilia. In 45% of the patients GOT and GPT and in 62% HBDH were moderately increased, while in 76% LDH and in 86% creatine-kinase showed abnormally high values. CK-MB was increased in three patients. 92% of muscle biopsies showed typical morphological changes in skeletal muscles. Latexagglutination, complement-fixation and agar-gel diffusion tests were not reliable. In most of the examined cases clinical symptoms and histological results correlated well with the indirect haemagglutination test, the microprecipitation test with living larvae of Trichinella spiralis and evidence of specific antibodies (IgG, IgM, IgE) by indirect immunofluorescence and the ELISA technique. 25 patients were treated with thiabendazole (Minzolum), 19 of them successfully.

摘要

食用野猪肉后,58名患者出现了旋毛虫病的典型临床症状和体征。所有患者均有明显的血液嗜酸性粒细胞增多。45%的患者谷草转氨酶(GOT)和谷丙转氨酶(GPT)以及62%的患者羟丁酸脱氢酶(HBDH)中度升高,而76%的患者乳酸脱氢酶(LDH)和86%的患者肌酸激酶显示异常高值。3名患者的肌酸激酶同工酶(CK-MB)升高。92%的肌肉活检显示骨骼肌有典型的形态学变化。乳胶凝集试验、补体结合试验和琼脂凝胶扩散试验不可靠。在大多数检查病例中,临床症状和组织学结果与间接血凝试验、旋毛虫活幼虫微量沉淀试验以及间接免疫荧光和酶联免疫吸附测定技术检测到的特异性抗体(IgG、IgM、IgE)结果相关性良好。25名患者接受了噻苯达唑(Minzolum)治疗,其中19名治疗成功。

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