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Observations on mebendazole vs. thiabendazole in the treatment of human trichinellosis.

作者信息

Horstmann R D, Kern P, Volkmer K J, Dietrich M

出版信息

Tropenmed Parasitol. 1982 Sep;33(3):191-4.

PMID:7135477
Abstract

Six patients with acute trichinellosis were studied. Three patients were treated with mebendazole and the other three with thiabendazole. Both drugs were given at a daily dose of 50 mg per kg body weight for seven consecutive days. No substantial differences were evident in the efficacy of the two drugs when symptoms, clinical findings, and laboratory data were followed for three months. However, mebendazole was better tolerated than thiabendazole. The diagnosis was based on epidemiological data and positive antibody tests. In two cases, diagnosis was confirmed by isolation of trichinella larvae from 10 ml blood samples filtered through polycarbonate membranes.

摘要

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引用本文的文献

1
Randomized trial of albendazole versus tiabendazole plus flubendazole during an outbreak of human trichinellosis.人类旋毛虫病暴发期间阿苯达唑与噻苯达唑加氟苯达唑对比的随机试验
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2
Cytotoxicity of mebendazole against established cell lines from the human, rat, and mouse liver.甲苯咪唑对源自人、大鼠和小鼠肝脏的已建细胞系的细胞毒性。
Arch Toxicol. 1992;66(3):224-7. doi: 10.1007/BF01974020.