Ally A I, Horrobin D F
Prostaglandins Med. 1980 Jun;4(6):431-8. doi: 10.1016/0161-4630(80)90051-8.
It has been thought that blood vessels apart from the umbilical artery produce little or no thromboxane (TX) A2. However selective inhibitors of TXA2 biosynthesis have substantial effects on vessel physiology, suggesting that small amounts of TXA2 may be important in regulating function. This indirect evidence is now supported by direct measurements of TXB2 (the produce of TXA2 conversion) using both gas chromatography-mass spectrometry (GCMS) and radioimmunoassays. At least four independent laboratories have now demonstrated TXB2 production by various blood vessels. These studies suggest that vessel wall TXA2 is present in amounts more than adequate to exert biological actions on both vascular reactivity and on platelets. This may require re-evaluation and revision of present concepts of hypertension and thrombosis.
人们一直认为，除脐动脉外的血管几乎不产生或不产生血栓素（TX）A2。然而，TX A2生物合成的选择性抑制剂对血管生理有显著影响，这表明少量的TX A2可能在调节功能方面很重要。现在，使用气相色谱-质谱联用仪（GCMS）和放射免疫分析法对TXB2（TX A2转化产物）的直接测量支持了这一间接证据。现在至少有四个独立实验室证明了各种血管能产生TXB2。这些研究表明，血管壁中的TX A2含量足以对血管反应性和血小板产生生物学作用。这可能需要重新评估和修正目前关于高血压和血栓形成的概念。
