揭示纤毛在神经胶质细胞发育中的作用。
Uncovering cilia function in glial development.
机构信息
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
Neuroscience Graduate Program, Emory University, Atlanta, Georgia, USA.
出版信息
Ann Hum Genet. 2024 Jan;88(1):27-44. doi: 10.1111/ahg.12519. Epub 2023 Jul 10.
Primary cilia play critical roles in regulating signaling pathways that underlie several developmental processes. In the nervous system, cilia are known to regulate signals that guide neuron development. Cilia dysregulation is implicated in neurological diseases, and the underlying mechanisms remain poorly understood. Cilia research has predominantly focused on neurons and has overlooked the diverse population of glial cells in the brain. Glial cells play essential roles during neurodevelopment, and their dysfunction contributes to neurological disease; however, the relationship between cilia function and glial development is understudied. Here we review the state of the field and highlight the glial cell types where cilia are found and the ciliary functions that are linked to glial development. This work uncovers the importance of cilia in glial development and raises outstanding questions for the field. We are poised to make progress in understanding the function of glial cilia in human development and their contribution to neurological diseases.
初级纤毛在调节信号通路方面起着至关重要的作用，这些信号通路是几种发育过程的基础。在神经系统中，纤毛被认为可以调节指导神经元发育的信号。纤毛调节异常与神经疾病有关，但其潜在机制仍知之甚少。纤毛研究主要集中在神经元上，而忽视了大脑中多样化的神经胶质细胞群体。神经胶质细胞在神经发育过程中起着至关重要的作用，其功能障碍导致神经疾病；然而，纤毛功能与神经胶质发育之间的关系还研究得不够。在这里，我们回顾了这一领域的现状，并强调了发现纤毛的神经胶质细胞类型以及与神经胶质发育相关的纤毛功能。这项工作揭示了纤毛在神经胶质发育中的重要性，并为该领域提出了悬而未决的问题。我们有望在理解人类发育过程中神经胶质纤毛的功能及其对神经疾病的贡献方面取得进展。
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