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睾丸肿瘤患者中针对畸胎癌特异性抗原的循环抗体检测。

Detection of the circulating antibodies to teratocarcinomadefined antigens in patients with testicular tumours.

作者信息

Teodorczyk-Injeyan J, Jewett M A, Burke C A, Ostrand-Rosenberg S

出版信息

Clin Exp Immunol. 1980 Jun;40(3):438-44.

PMID:6998614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538930/
Abstract

Sera from twenty-three patients with primary or metastatic testicular tumours of germinal origin were tested for antibodies against teratocarcinoma-associated antigen(s), using an indirect immunofluorescence technique. Human and 129/Sv mouse sperm and mouse teratocarcinoma cell line 402 AX were used as target cells. A total of fifteen sera were identified as positive, six of them when tested against both sperm and tumour cells. Tail staining has been the most prevalent pattern of fluorescence on both human and murine spermatozoa. These observations suggest that antibody to a common teratoma-defined antigen(s) was detected in sera of patients with testicular tumours.

摘要

采用间接免疫荧光技术，检测了23例原发性或转移性生殖细胞起源睾丸肿瘤患者血清中针对畸胎癌相关抗原的抗体。使用人及129/Sv小鼠精子和小鼠畸胎癌细胞系402AX作为靶细胞。共鉴定出15份血清呈阳性，其中6份血清在同时检测精子和肿瘤细胞时呈阳性。尾染色是人和小鼠精子上最常见的荧光模式。这些观察结果表明，在睾丸肿瘤患者血清中检测到了针对一种常见的畸胎瘤定义抗原的抗体。

相似文献

1
Detection of the circulating antibodies to teratocarcinomadefined antigens in patients with testicular tumours.睾丸肿瘤患者中针对畸胎癌特异性抗原的循环抗体检测。
Clin Exp Immunol. 1980 Jun;40(3):438-44.
2
Antisperm antibodies in mouse vasectomy sera react with embryonal teratocarcinoma.小鼠输精管切除术后血清中的抗精子抗体与胚胎性睾丸癌发生反应。
J Immunol. 1983 Dec;131(6):2908-12.
3
Antibodies to large glycopeptides in sera from patients with ovarian germ cell tumours.卵巢生殖细胞肿瘤患者血清中针对大型糖肽的抗体。
Clin Exp Immunol. 1983 Feb;51(2):401-6.
4
Teratocarcinoma antigen is secreted by epididymal cells and coupled to maturing sperm.
Exp Cell Res. 1982 Feb;137(2):485-8. doi: 10.1016/0014-4827(82)90058-1.
5
[Mouse teratocarcinoma: studies of antigens at the surface of multipotential cells (author's transl)].
Ann Microbiol (Paris). 1974 Oct-Nov;125B(3):347-56.
6
[Experimental teratocarcinoma in mice: a model system for the study of the relationship between cellular surface antigens and embryonic differentiation].[小鼠实验性畸胎癌：用于研究细胞表面抗原与胚胎分化之间关系的模型系统]
Bull Cancer. 1976 Jan-Mar;63(1):95-110.
7
Antibodies against surface antigens common to spermatogenic and F9 teratocarcinoma cells in mice immunized with blood group substances from human saliva.用人唾液中的血型物质免疫的小鼠体内，针对生精细胞和F9畸胎瘤细胞共有的表面抗原的抗体。
Exp Clin Immunogenet. 1985;2(3):174-82.
8
Cell surface antigens of a mouse testicular teratoma. Identification of an antigen physically associated with H-2 antigens on tumor cells.小鼠睾丸畸胎瘤的细胞表面抗原。肿瘤细胞上与H-2抗原物理相关的一种抗原的鉴定。
J Exp Med. 1974 Jul 1;140(1):61-78. doi: 10.1084/jem.140.1.61.
9
[Cross-reacting epithelial antigen of ectodermal origin in mouse tumors].[小鼠肿瘤中起源于外胚层的交叉反应性上皮抗原]
Vopr Onkol. 1977;23(10):83-7.
10
Apparent lack of immunogenicity of estrogen-induced testicular Leydig cell tumors in BALB/c mice.雌激素诱导的BALB/c小鼠睾丸间质细胞瘤明显缺乏免疫原性。
Cancer Res. 1982 Nov;42(11):4332-8.

引用本文的文献

1
Exocrine function of testis with germinal testicular tumour.伴有生殖细胞睾丸肿瘤的睾丸外分泌功能
Br Med J (Clin Res Ed). 1983 Jun 11;286(6381):1849-50. doi: 10.1136/bmj.286.6381.1849.

本文引用的文献

1
Experimental production of testicular teratomas in mice of strains 129, A/He, and their F1 hybrids.129品系、A/He品系小鼠及其F1杂交后代中睾丸畸胎瘤的实验性诱导
J Natl Cancer Inst. 1970 Apr;44(4):923-9.
2
Origin of testicular teratomas from primordial germ cells in mice.小鼠睾丸畸胎瘤起源于原始生殖细胞。
J Natl Cancer Inst. 1967 Apr;38(4):549-52.
3
Immunofluorescent studies on human spermatozoa. II. Characterization of spermatozoal antigens and their occurrence in spermatozoa from the male partners of infertile couples.人类精子的免疫荧光研究。II. 精子抗原的特征及其在不育夫妇男性伴侣精子中的存在情况。
Clin Exp Immunol. 1971 Jul;9(1):21-31.
4
Immunofluorescent studies on human spermatozoa. I. The detection of different spermatozoal antibodies and their occurrence in normal and infertile women.人类精子的免疫荧光研究。I. 不同精子抗体的检测及其在正常和不孕女性中的出现情况。
Clin Exp Immunol. 1971 Jan;8(1):9-23.
5
[Fluorescence immunology findings on spermatozoan autoantibodies in male fertility disorders].[男性生育障碍中精子自身抗体的荧光免疫研究结果]
Arch Gynakol. 1969;208(2):91-102. doi: 10.1007/BF00668187.
6
Similar location of an early embryonic antigen on mouse and human spermatozoa.小鼠和人类精子上早期胚胎抗原的相似定位。
Dev Biol. 1974 Dec;41(2):331-7. doi: 10.1016/0012-1606(74)90310-8.
7
Immunofluorescent studies on human spermatozoa. 3. Immunoglobulin classes of human spermatozoal antibodies.人类精子的免疫荧光研究。3. 人类精子抗体的免疫球蛋白类别。
Clin Exp Immunol. 1972 Feb;10(2):243-9.
8
Immunofluorescent studies on mammalian spermatozoa: antigenic relationship between human, bull and rabbit spermatozoa.
J Reprod Fertil. 1972 Apr;29(1):19-28. doi: 10.1530/jrf.0.0290019.
9
Presence of a mouse embryonic antigen on human spermatozoa.人类精子上存在小鼠胚胎抗原。
Proc Natl Acad Sci U S A. 1974 May;71(5):1730-3. doi: 10.1073/pnas.71.5.1730.
10
Cell surface antigens of a mouse testicular teratoma. Identification of an antigen physically associated with H-2 antigens on tumor cells.小鼠睾丸畸胎瘤的细胞表面抗原。肿瘤细胞上与H-2抗原物理相关的一种抗原的鉴定。
J Exp Med. 1974 Jul 1;140(1):61-78. doi: 10.1084/jem.140.1.61.