Leenen F H, Boer P, Dorhaut Mees E J
Clin Exp Hypertens (1978). 1980 Feb;2(2):197-211. doi: 10.3109/10641968009046420.
In young normotensive women (5 without and 5 with chronic oral contraceptives (= o.c.) cardiovascular homeostasis was challenged by isoproterenol and ergometer exercise, at normal and at resitricted sodium intake. Blood pressure and plasma renin activity (= PRA) did not differ between the 2 groups. Plasma renin substrate was markedly elevated in the o.c. group. Sodium restriction induced similar changes in body weight, urinary sodium excretion, systolic blood pressure and PRA; diastolic blood pressure decreased only in the non-o.c. group (by 6 mm Hg). In both groups isoproterenol and exercise induced similar changes in heart rate and blood pressure, except that after sodium restriction both stimuli caused larger decreases in diastolic blood pressure in the o.c. group. At both levels of sodium intake, PRA increased slightly less during exercise in the o.c. group; following restriction PRA response to isoproterenol was significantly less in the o.c. group. These results indicate that following chronic use of o.c. PRA responsiveness is normal or somewhat blunted. The different responses of diastolic blood pressure to sodium restriction and subsequent isoproterenol or exercise point to subtle changes in the inter-action of aodium and pressor mechanisms during chronic o.c. use.
在年轻血压正常的女性中（5名未服用和5名长期服用口服避孕药（=o.c.）），通过异丙肾上腺素和测力计运动，在正常和限制钠摄入的情况下对心血管稳态进行了挑战。两组之间的血压和血浆肾素活性（=PRA）没有差异。口服避孕药组的血浆肾素底物明显升高。钠限制引起体重、尿钠排泄、收缩压和PRA的类似变化；舒张压仅在未服用口服避孕药组中降低（降低6mmHg）。在两组中，异丙肾上腺素和运动引起心率和血压的类似变化，只是在钠限制后，两种刺激在口服避孕药组中引起的舒张压下降幅度更大。在两种钠摄入水平下，口服避孕药组运动期间PRA的升高略少；限制钠摄入后，口服避孕药组对异丙肾上腺素的PRA反应明显更小。这些结果表明，长期使用口服避孕药后PRA反应性正常或略有减弱。舒张压对钠限制以及随后的异丙肾上腺素或运动的不同反应表明，长期使用口服避孕药期间钠与升压机制的相互作用发生了细微变化。
