钠摄入量以及异丙肾上腺素和运动对人体血浆肾素的影响。

Sodium intake and the effects of isoproterenol and exercise on plasma renin in man.

作者信息

Leenen F H, Boer P, Geyskes G G

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):870-4. doi: 10.1152/jappl.1978.45.6.870.

DOI:10.1152/jappl.1978.45.6.870

Abstract

Changes in heart rate, blood pressure, and plasma renin activity (PRA) were assessed during infusion of increasing doses of isoproterenol and during increasing work loads of dynamic exercise in five normal young men. Studies were performed at three levels of dietary sodium restriction: normal, moderately, and more severely restricted. Isoproterenol induced the expected dose-related increases in heart rate, systolic blood pressure, and PRA and decreases in diastolic blood pressure. Changes in dietary sodium intake affected these changes only to a minor degree. Dynamic exercise also induced the expected work-load-related increases in heart rate, systolic blood pressure, and PRA and decreases in diastolic blood pressure. Also these changes were not significantly affected by changes in dietary sodium intake. Apparently dietary sodium restriction does not sensitize the renin-releasing mechanisms to sympathetic stimulation.

摘要

在五名正常年轻男性中，分别在输注递增剂量的异丙肾上腺素期间以及动态运动负荷增加期间，评估心率、血压和血浆肾素活性（PRA）的变化。研究在三种饮食钠限制水平下进行：正常、中度和更严格限制。异丙肾上腺素引起心率、收缩压和PRA预期的剂量相关增加以及舒张压降低。饮食钠摄入量的变化仅在较小程度上影响这些变化。动态运动也引起心率、收缩压和PRA预期的与工作负荷相关的增加以及舒张压降低。同样，这些变化也未受到饮食钠摄入量变化的显著影响。显然，饮食钠限制不会使肾素释放机制对交感神经刺激敏感。