Mison P, Viklický J, Strnad V, Trnka L
Czech Med. 1980;3(2):176-82.
There are described the histological changes in the lung tissue of mice after airborne infection with the strains of Klebsiella pneumoniae CNCTC Klp 80/66 and CNCTC 82/67 whose clearance is significantly different. Using the strain Klp 82/67, which is fairly prompt eliminated from lungs, no morphological changes in the mucous membrane of bronchi were found. Using the strain Klp 80/66, which is characterised by a multiplication of organisms in the lungs already in the initial phase of infection without any remarkable adaptative phase, the accumulation of neutrophils in the walls and on the surface of bronchi was observed. The accumulation retarded during 48 hours when mostly the mononuclear cells were present. Uptake of 3H-thymidine in the lung tissue in vivo demonstrated that the proliferation response of bronchial lymphoid tissue is a relatively early reaction. Histological examination of spontaneously died animals revealed the changes characteristic for the purulent bronchopneumonia. The pathogenic activity of various Klebsiella pneumoniae strains is obviously conditioned by at least two factors, i. e. by surface structures determining the rate of bacterial elimination from the lungs and by the lipoprotein components of the cell walls inducing the leucocytes mobilization into bronchial tissue.
描述了小鼠经空气传播感染肺炎克雷伯菌CNCTC Klp 80/66和CNCTC 82/67菌株后肺组织的组织学变化，这两种菌株的清除率有显著差异。使用从肺部相当迅速清除的Klp 82/67菌株，未发现支气管黏膜有形态学变化。使用Klp 80/66菌株，其特点是在感染初期肺部细菌就开始繁殖，没有明显的适应期，观察到支气管壁和表面有中性粒细胞积聚。在48小时内积聚减缓，此时主要是单核细胞。体内肺组织对3H-胸腺嘧啶核苷的摄取表明，支气管淋巴组织的增殖反应是一种相对早期的反应。对自然死亡动物的组织学检查显示出脓性支气管肺炎的特征性变化。各种肺炎克雷伯菌菌株的致病活性显然至少受两个因素制约，即决定细菌从肺部清除速度的表面结构和诱导白细胞向支气管组织动员的细胞壁脂蛋白成分。
