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在大肠杆菌细胞膜-细胞分裂基因簇中鉴定新基因：细胞分裂基因ftsQ。

Identification of new genes in a cell envelope-cell division gene cluster of Escherichia coli: cell division gene ftsQ.

作者信息

Begg K J, Hatfull G F, Donachie W D

出版信息

J Bacteriol. 1980 Oct;144(1):435-7. doi: 10.1128/jb.144.1.435-437.1980.

DOI:10.1128/jb.144.1.435-437.1980
PMID:6998961
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC294678/
Abstract

We report the identification, cloning, and mapping of a new cell division gene, ftsQ. This gene formed part of a cluster of three division genes (in the order ftsQ ftsA ftsZ) which itself formed part of a larger cluster of at least 10 genes, all of which were involved in some step in cell division, cell envelope synthesis, or both. The ftsQAZ group was transcribed from at least two independent promoters.

摘要

我们报告了一个新的细胞分裂基因ftsQ的鉴定、克隆和定位。该基因是由三个分裂基因组成的基因簇的一部分（顺序为ftsQ ftsA ftsZ），而这个基因簇本身又是一个至少包含10个基因的更大基因簇的一部分，所有这些基因都参与细胞分裂、细胞包膜合成或两者的某些步骤。ftsQAZ基因组由至少两个独立的启动子转录。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4135/294678/9289ab2c070b/jbacter00571-0450-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4135/294678/9289ab2c070b/jbacter00571-0450-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4135/294678/9289ab2c070b/jbacter00571-0450-a.jpg

相似文献

1
Identification of new genes in a cell envelope-cell division gene cluster of Escherichia coli: cell division gene ftsQ.在大肠杆菌细胞膜-细胞分裂基因簇中鉴定新基因：细胞分裂基因ftsQ。
J Bacteriol. 1980 Oct;144(1):435-7. doi: 10.1128/jb.144.1.435-437.1980.
2
Structure and expression of the cell division genes ftsQ, ftsA and ftsZ.细胞分裂基因ftsQ、ftsA和ftsZ的结构与表达。
J Mol Biol. 1985 Aug 5;184(3):399-412. doi: 10.1016/0022-2836(85)90290-6.
3
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.通过扩增包含紧密排列的细胞分裂和细胞生长基因的染色体区域来抑制大肠杆菌ftsQ、ftsA和ftsZ突变细胞的生长。
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4
DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units.大肠杆菌必需细胞分裂基因ftsQ和ftsA的DNA序列及转录组织：转录单元重叠的证据。
J Bacteriol. 1984 Nov;160(2):546-55. doi: 10.1128/jb.160.2.546-555.1984.
5
Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments.大肠杆菌同基因ftsZ、ftsQ、ftsA、pbpB和ftsE细胞分裂突变体在温度转换实验期间的分裂行为和形态变化。
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6
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Identification of new genes in a cell envelope-cell division gene cluster of Escherichia coli: cell envelope gene murG.大肠杆菌细胞膜-细胞分裂基因簇中新基因的鉴定：细胞膜基因murG
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Regulation of cell division in Escherichia coli K-12: probable interactions among proteins FtsQ, FtsA, and FtsZ.大肠杆菌K-12中细胞分裂的调控：蛋白质FtsQ、FtsA和FtsZ之间可能的相互作用。
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Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ).大肠杆菌遗传图谱中ftsA-envA区域的基因组织及一个新的fts位点（ftsZ）的鉴定。
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本文引用的文献

1
THE SELECTION OF MUTANTS OF ESCHERICHIA COLI WITH IMPAIRED CELL DIVISION AT ELEVATED TEMPERATURE.大肠杆菌在高温下细胞分裂受损的突变体的筛选
Mutat Res. 1964 Jul;106:121-8. doi: 10.1016/0027-5107(64)90014-4.
2
Identification of new genes in a cell envelope-cell division gene cluster of Escherichia coli: cell envelope gene murG.大肠杆菌细胞膜-细胞分裂基因簇中新基因的鉴定：细胞膜基因murG
J Bacteriol. 1980 Oct;144(1):438-40. doi: 10.1128/jb.144.1.438-440.1980.
3
Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ).
细胞分裂受到促进细胞伸长的肽聚糖内切酶活性的拮抗。
Mol Microbiol. 2020 Dec;114(6):966-978. doi: 10.1111/mmi.14587. Epub 2020 Aug 31.
4
Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.大肠杆菌ZapD的结构与突变分析揭示了参与FtsZ细丝成束的带电残基。
J Bacteriol. 2016 May 13;198(11):1683-1693. doi: 10.1128/JB.00969-15. Print 2016 Jun 1.
5
A mutation in Escherichia coli ftsZ bypasses the requirement for the essential division gene zipA and confers resistance to FtsZ assembly inhibitors by stabilizing protofilament bundling.大肠杆菌ftsZ基因的一个突变绕过了对必需分裂基因zipA的需求，并通过稳定原丝束化赋予对FtsZ组装抑制剂的抗性。
Mol Microbiol. 2015 Sep;97(5):988-1005. doi: 10.1111/mmi.13081. Epub 2015 Jul 4.
6
A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.一个加速分裂的ftsL等位基因揭示了FtsQLB复合体在细胞分裂环激活中的作用。
Mol Microbiol. 2015 Mar;95(6):925-44. doi: 10.1111/mmi.12905. Epub 2015 Jan 24.
7
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J Bacteriol. 1980 May;142(2):615-20. doi: 10.1128/jb.142.2.615-620.1980.
4
Process of cellular division in Escherichia coli: physiological study on thermosensitive mutants defective in cell division.大肠杆菌中的细胞分裂过程：对细胞分裂缺陷的热敏突变体的生理学研究
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A genetic map of several mutations affecting the mucopeptide layer of Escherichia coli.
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The construction in vitro of transducing derivatives of phage lambda.噬菌体λ转导衍生物的体外构建
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Role of the ftsA gene product in control of Escherichia coli cell division.
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