通过扩增包含紧密排列的细胞分裂和细胞生长基因的染色体区域来抑制大肠杆菌ftsQ、ftsA和ftsZ突变细胞的生长。
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
作者信息
Jung H K, Ishino F, Matsuhashi M
机构信息
Institute of Applied Microbiology, University of Tokyo, Japan.
出版信息
J Bacteriol. 1989 Nov;171(11):6379-82. doi: 10.1128/jb.171.11.6379-6382.1989.
Abstract
Amplification of a 2.6-kilobase chromosomal fragment of the mra region of Escherichia coli encompassing the ftsI(pbpB) gene and an open reading frame upstream with lethal to E. coli strains with mutations of the flanking cell division genes ftsQ, ftsA, and ftsZ. A shortened fragment in which the major portion of ftsI was deleted also had lethal effects on ftsQ and ftsZ mutants.
摘要
对大肠杆菌mra区域一个2.6千碱基的染色体片段进行扩增，该片段包含ftsI（pbpB）基因以及上游的一个开放阅读框，对侧翼细胞分裂基因ftsQ、ftsA和ftsZ发生突变的大肠杆菌菌株具有致死性。一个缺失了ftsI主要部分的缩短片段对ftsQ和ftsZ突变体也有致死作用。
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