Gilman R H, Koster F, Islam S, McLaughlin J, Rahaman M M
Antimicrob Agents Chemother. 1980 Mar;17(3):402-5. doi: 10.1128/AAC.17.3.402.
To establish optimal therapy for severe dysentery due to Shigella dysenteriae type 1 and Shigella flexneri, we compared in a prospective randomized trial two oral ampicillin doses (50 and 150 mg/kg per day) in 57 children and 39 adults in Dacca, Bangladesh. Clinical failure did not occur in either group, indicating that conventional doses need not be increased even in severe disease. Among children 3 years of age or under, bacteriological relapses tended to be more frequent in the low-dose group and were not related to serum levels of ampicillin, nutritional status, or the severity of colitis on admission. Therefore, we recommend that younger children be treated with 100 mg/kg per day of oral ampicillin.
为确定针对1型痢疾志贺菌和福氏志贺菌所致严重痢疾的最佳治疗方法，我们在孟加拉国达卡对57名儿童和39名成人进行了一项前瞻性随机试验，比较了两种口服氨苄西林剂量（每日50和150 mg/kg）。两组均未出现临床治疗失败，这表明即使是重症疾病，常规剂量也无需增加。在3岁及以下儿童中，低剂量组的细菌学复发往往更频繁，且与氨苄西林的血清水平、营养状况或入院时结肠炎的严重程度无关。因此，我们建议年幼儿童采用每日100 mg/kg的口服氨苄西林进行治疗。
