Duncan S C, Evans H L, Winkelmann R K
Arch Dermatol. 1980 Oct;116(10):1142-6.
We studied nine cases of cutaneous lymphoproliferative disease that shared a distinct histologic pattern. The lesions consisted of red-to-violaceous, single or clustered, deep papules or nodules. They proved to be benign on long-term evaluation. Nodular infiltrates of large, pleomorphic lymphocytes, sometimes appearing to be histiocytic and often associated with frequent mitoses, led to the diagnosis of lymphoma or reticulum cell sarcoma in seven of the cases. Sharply marginated, dense clusters of small lymphocytes surrounded or infiltrated the large cell component, a juxtaposition that characterizes large cell lymphocytoma. This pattern was not found in patients with progressive malignant lymphoma. At times, multiple biopsies must be done to establish the diagnosis. All patients are alive, and none has malignant lymphoma. The follow-up periods for six of the patients have been five years or longer.
我们研究了9例具有独特组织学模式的皮肤淋巴增生性疾病。病变表现为红色至紫罗兰色的单个或成簇的深部丘疹或结节。长期评估显示这些病变为良性。在7例病例中，大量多形性淋巴细胞的结节状浸润，有时看似组织细胞性且常伴有频繁的有丝分裂，导致诊断为淋巴瘤或网状细胞肉瘤。边界清晰、密集的小淋巴细胞簇围绕或浸润大细胞成分，这种并列情况是大细胞淋巴细胞瘤的特征。在进行性恶性淋巴瘤患者中未发现这种模式。有时，必须进行多次活检才能确诊。所有患者均存活，且无一人患有恶性淋巴瘤。其中6例患者的随访期已达5年或更长时间。
