Kaukinen S, Eerola M, Ylitalo P
Br J Anaesth. 1980 Jun;52(6):603-7. doi: 10.1093/bja/52.6.603.
In a double-blind study, probenecid 0.5 or 1.0 g or placebo was given to 86 patients undergoing uterine curettage or gynaecological laparotomy 3 h before operation. The duration of anaesthesia in patients anaesthetized with thiopentone 7 mg kg-1 and premedicated with pethidine and atropine, was prolonged by 65% by probenecid 0.5 g, and by 46% by probenecid 1.0 g, compared with control (P < 0.05). In the absence of pethidine premedication, probenecid 0.5 g prolonged anaesthesia by 26% (P < 0.1). In patients without pethidine premedication anaesthetized with only thiopentone 4 mg kg-1 but who had no surgical stimulus during anaesthesia, probenecid increased the duration of the anaesthesia by 109% (P < 0.1). In this group the frequency of sleeping was 100%, as compared with 80% in the placebo-treated patients. Probenecid did not modify the response to pain and had no effect on apnoea, arterial pressure or heart rate.
在一项双盲研究中，在手术前3小时，给86例接受刮宫术或妇科剖腹术的患者服用0.5克或1.0克丙磺舒或安慰剂。用7毫克/千克硫喷妥钠麻醉并用哌替啶和阿托品进行术前用药的患者，与对照组相比，0.5克丙磺舒使麻醉持续时间延长65%，1.0克丙磺舒使麻醉持续时间延长46%（P<0.05）。在没有哌替啶术前用药的情况下，0.5克丙磺舒使麻醉时间延长26%（P<0.1）。在仅用4毫克/千克硫喷妥钠麻醉但麻醉期间无手术刺激的未用哌替啶术前用药的患者中，丙磺舒使麻醉持续时间延长109%（P<0.1）。在该组中，睡眠频率为100%，而安慰剂治疗患者为80%。丙磺舒未改变对疼痛的反应，对呼吸暂停、动脉血压或心率无影响。
