Shimizu M, Miura M, Kitahara M, Katayama I
Am J Pathol. 1982 Jan;106(1):30-9.
Recently the Lymphoma Study Group of Japan (LSGJ) proposed a new classification of non-Hodgkin's lymphomas (NHLs), diving NHLs into the follicular group consisting of three subsets and the diffuse group, 7. Each subset of the diffuse group is further divided into B or T cell types according to immunologic markers and/or morphologic prediction. In the review of 118 malignant lymphomas, the authors studied the 109 cases of NHLs, attempting to assess the clinicopathologic utility of this classification. Morphologic criteria, enzyme histochemistry, and immunoperoxidase technique were used to ensure the accuracy of the immunologic phenotyping. The results suggest that the LSGJ classification is easily reproducible and yields a more precise clinicopathologic correlation than traditional, morphologic classifications. Consistent with similar studies in Japan, this study demonstrated a low incidence of Hodgkin's disease (7.6% of all lymphomas) and follicular lymphomas (8.3% of all NHLs) and a high incidence of T cell lymphomas (34.9% of all NHLs). The incidence (45.9%) of extranodal presentation was high. These four features seem characteristic of lymphomas in Japan.
最近，日本淋巴瘤研究小组（LSGJ）提出了一种非霍奇金淋巴瘤（NHL）的新分类方法，将NHL分为由三个亚组组成的滤泡性淋巴瘤组和弥漫性淋巴瘤组。弥漫性淋巴瘤组的每个亚组再根据免疫标志物和/或形态学预测进一步分为B细胞型或T细胞型。在对118例恶性淋巴瘤的回顾中，作者研究了109例NHL，试图评估这种分类方法在临床病理方面的实用性。采用形态学标准、酶组织化学和免疫过氧化物酶技术来确保免疫表型分析的准确性。结果表明，LSGJ分类方法易于重复，并且与传统的形态学分类相比，能产生更精确的临床病理相关性。与日本的类似研究一致，本研究显示霍奇金病（占所有淋巴瘤的7.6%）和滤泡性淋巴瘤（占所有NHL的8.3%）的发病率较低，而T细胞淋巴瘤的发病率较高（占所有NHL的34.9%）。结外表现的发病率较高（45.9%）。这四个特征似乎是日本淋巴瘤的特点。
