von Melchner H, Metcalf D, Mandel T E
Blood. 1980 Nov;56(5):917-22.
After lethal irradiation of C57BL mice followed by the injection of 10(7) marrow cells, total cellularity and progenitor cell levels exceeded pretreatment levels within 12 days in the spleen, but regeneration remained incomplete in the marrow. The exceptional regenerative capacity of progenitor populations in the spleen was observed in organ cultures of spleen slices prepared 24 hr after irradiation and transplantation, excluding continuous repopulation from the marrow as a significant factor in splenic regeneration.
对C57BL小鼠进行致死性照射后，注射10^7个骨髓细胞，脾脏中的总细胞数和祖细胞水平在12天内超过了预处理水平，但骨髓中的再生仍不完全。在照射和移植后24小时制备的脾脏切片器官培养物中观察到脾脏中祖细胞群体的特殊再生能力，排除了骨髓持续再填充作为脾脏再生的一个重要因素。
