Rösen P, Schrör K
Diabetologia. 1980 May;18(5):391-4. doi: 10.1007/BF00276820.
The release of prostacyclin and PGE2 from the isolated perfused hearts of acutely diabetic (streptozotocin 100 mg/kg) rats was studied and compared with hearts from control animals. Prostacyclin and PGE2 were measured by a differential bioassay technique. No basal release of either prostaglandin ws detected. However, after addition of arachidonic acid, a dose dependent release of prostacyclin and PGE2 was noted. Prostacyclin was identified as the major prostaglandin. Release of prostacyclin and PGE2 from acutely diabetic rat hearts was increased 2-3 times compared to control hearts. No release of prostaglandin endoperoxides was observed in either group of hearts.
研究了急性糖尿病（链脲佐菌素100mg/kg）大鼠离体灌注心脏中前列环素和前列腺素E2的释放情况，并与对照动物的心脏进行了比较。采用差异生物测定技术测定前列环素和前列腺素E2。未检测到两种前列腺素的基础释放。然而，加入花生四烯酸后，观察到前列环素和前列腺素E2呈剂量依赖性释放。前列环素被确定为主要的前列腺素。与对照心脏相比，急性糖尿病大鼠心脏中前列环素和前列腺素E2的释放增加了2至3倍。两组心脏均未观察到前列腺素内过氧化物的释放。
