Iatsyno A I, Belova L F, Lipkina G S, Sokolov S I, Trutneva E A
Farmakol Toksikol. 1978 Sep-Oct;41(5):556-60.
Calendulozide B--trioside of oleanolic acid, isolated from rhizomes of Calendula officinalis, Fam. Compositae, used perorally in doses of 5, 10, 20 and 50 mg/kg exerted an antiulcerous action in 3 experimental ulcer models of different genesis (caffein-arsenic, butadion and induced by ligation of pylorus) and also displayed a certain antiphlogistic and sedative action. It did not have any effect on the cardiovascular system, the tone of intestinal smooth muscles, diuretic renal function and electrolytes excretion with urine or on the biligenic function of the liver. The drug is devoid of locally irritation properties, manifests a relatively low hemolytic activity (15000 after Kofler) and an insignificant toxicity both with its one-time and chronic administration.
金盏花苷B——齐墩果酸三糖苷，从菊科植物金盏花的根茎中分离得到，口服剂量为5、10、20和50mg/kg时，在3种不同病因的实验性溃疡模型（咖啡因-砷、布他酮和幽门结扎诱导）中发挥抗溃疡作用，还表现出一定的抗炎和镇静作用。它对心血管系统、肠道平滑肌张力、利尿肾功能和尿电解质排泄或肝脏的胆汁生成功能均无影响。该药物无局部刺激性，溶血活性相对较低（科弗勒法测定后为15000），单次给药和长期给药时毒性均不显著。
