Kawasaki T, Uezono K, Ueno M, Noda Y, Kumamoto K, Kawano Y, Ogata M, Fukiyama K, Omae T, Bartter F C
Jpn Heart J. 1980 Sep;21(5):681-92. doi: 10.1536/ihj.21.681.
In a study of 14 patients (11 Japanese and 3 white North Americans) with aldosterone-producing tumor carried out within 2 to 4 weeks after unilateral adrenalectomy, both plasma renin activity (PRA) and plasma aldosterone concentration (PAC) increased almost normally with short-term sodium depletion and upright posture. Aldosterone excretion rate (AER) also increased significantly with sodium depletion, and was normally suppressed by sodium loading. Highly significant correlations were observed between PRA and PAC (r=0.89, p < 0.001) or AER (r=0.88, p < 0.001) ater operation, whereas there had been no such correlation before operation. Either physiological or laboratory findings were normalized or markedly improved in all cases although pathohistological diagnosis was made as adenomatous hyperplasia in 10 out of 11. These results indicate that within 4 weeks of operation PRA and the remaining adrenal gland can almost normally respond to stimuli such as sodium depletion and upright posture regardless of the amount of spironolactone given preoperatively.
在一项对14例醛固酮分泌瘤患者（11例日本人和3例北美白人）的研究中，这些患者在单侧肾上腺切除术后2至4周内接受了研究，血浆肾素活性（PRA）和血浆醛固酮浓度（PAC）在短期钠缺乏和直立姿势下几乎正常增加。醛固酮排泄率（AER）也随着钠缺乏而显著增加，并且在钠负荷时通常受到抑制。术后观察到PRA与PAC（r = 0.89，p < 0.001）或AER（r = 0.88，p < 0.001）之间存在高度显著的相关性，而术前不存在这种相关性。尽管11例中有10例病理组织学诊断为腺瘤样增生，但所有病例的生理或实验室检查结果均恢复正常或明显改善。这些结果表明，术后4周内，无论术前给予螺内酯的量如何，PRA和剩余的肾上腺几乎可以正常响应钠缺乏和直立姿势等刺激。
