Zipursky A, Milner R A, Blanchette V S, Johnston M A
Pediatrics. 1980 Oct;66(4):547-50.
A double-blind randomized trial of vitamin E therapy was conducted in premature infants whose birth weight was less than 1,500 gm. Treated infants received 25 mg of vitamin E daily by mouth for the first six weeks of life. Detailed studies of plasma coagulation factors were performed prior to therapy and at days 7 and 42. None of the factors differed significantly between the treated and control groups. Although vitamin E therapy has been reported to affect the blood levels of vitamin K dependent coagulation factors, no such effect was noted in this group of premature infants.
对出生体重低于1500克的早产儿进行了一项维生素E治疗的双盲随机试验。接受治疗的婴儿在出生后的前六周每天口服25毫克维生素E。在治疗前以及第7天和第42天对血浆凝血因子进行了详细研究。治疗组和对照组之间的任何因子均无显著差异。尽管据报道维生素E治疗会影响维生素K依赖性凝血因子的血液水平，但在这组早产儿中未观察到此类影响。
