松果体多肽和褪黑素对成年雄性大鼠血清及垂体促黄体生成素和促卵泡生成素的影响。
The effect of pineal polypeptides and melatonin on serum and pituitary LH and FSH in adult male rats.
作者信息
Damian E, Ianăş O, Bădescu I
出版信息
Endocrinologie. 1980 Jul-Sep;18(3):155-9.
The effect of a pineal polypeptide extract was tested against the effect of melatonin on the serum level and pituitary concentration of LH and FSH of the adult male rat both in basal conditions and in response to exogenous (GnRH) and endogenous (castration) stimulation. A 2 ml dose of pineal polypeptides per injection caused a signifcant fall in serum LH and FSH both in the intact, the intact + GnRH, and the castrated animals. The decrease in pituitary concentration of LH and FSH was of statistical significance only in stimulation conditions. A 50 micrograms dose of melatonn/injection failed to produce comparable effects. The antigondaotropic action of the biologically active pineal compounds is discussed.
在基础条件下以及对外源（促性腺激素释放激素，GnRH）和内源（去势）刺激的反应中，测试了松果体多肽提取物对成年雄性大鼠血清中促黄体生成素（LH）和促卵泡生成素（FSH）水平以及垂体中LH和FSH浓度的影响，同时与褪黑素的作用进行了对比。每次注射2毫升松果体多肽剂量，可使完整动物、完整+GnRH动物以及去势动物的血清LH和FSH均显著下降。仅在刺激条件下，垂体中LH和FSH浓度的降低具有统计学意义。每次注射50微克褪黑素未能产生类似效果。文中讨论了生物活性松果体化合物的抗促性腺作用。
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