Ninkov V, Piletić O, Karanović D
Strahlentherapie. 1980 Nov;156(11):800-3.
Haemoregeneration after the irradiation with 600 R was studied using two different fractions given before and after the transplantation of bone-marrow cells. The dose of 600 R was divided in two uneven fractions: 500 + 100 R, 400 + 200 R and 300 + 300 R. During the free interval between the two doses (5 min) transplantation of bone-marrow cells was performed. Recolonization of bone-marrow and spleen was analysed on the 10th day after treatment. For analysis, samples of blood, bone-marrow and spleen were used. Maximal effect was found in the experimental group of animals irradiated with 500 R before and with 100 R after marrow-cell transplantation. Minimal haematopoietic response was in the group irradiated with 300 R before and after transplantation. This points at the importance of the primary dose for acceptance of the transplants and their activation.
使用在骨髓细胞移植前后给予的两种不同剂量，研究了600伦琴照射后的血液再生情况。600伦琴的剂量被分为两个不均匀的剂量：500 + 100伦琴、400 + 200伦琴和300 + 300伦琴。在两次剂量之间的空闲间隔（5分钟）内进行骨髓细胞移植。在治疗后第10天分析骨髓和脾脏的再定植情况。分析时使用了血液、骨髓和脾脏样本。在骨髓细胞移植前接受500伦琴照射且移植后接受100伦琴照射的实验组动物中发现了最大效应。移植前后均接受300伦琴照射的组造血反应最小。这表明初始剂量对于移植的接受及其激活的重要性。
