Ninkov V, Piletić O, Karanović D
Strahlentherapie. 1980 Nov;156(11):786-9.
The effect of the same dose of irradiation (600 R) divided into two different fractions (500 + 100 R; 400 + 200 R; 300 + 300 R) upon the haematopoietic system of young rats (25 days old) was investigated. Free interval between the first and the second dose was 5 minutes. Changes were observed in bone-marrow, spleen and blood in all the experimental groups of 10 days after the irradiation. Spontaneous regeneration of haematopoiesis after a single dose of 600 R is higher than after division of this dose into two fractions, excluding the group where the dose was divided into two equal fractions. The most intensive haematopoietic repopulation was found in the group of rats irradiated with 300 + 300 R, where the primary dose was the smallest. In fractional conditions, the first dose is of primary importance for the repopulating capacity of the haematopoietic system regardless of the short free interval.
研究了将相同剂量的辐射（600伦琴）分为两种不同分次剂量（500 + 100伦琴；400 + 200伦琴；300 + 300伦琴）对幼鼠（25日龄）造血系统的影响。第一次和第二次剂量之间的间隔时间为5分钟。在照射后10天观察所有实验组的骨髓、脾脏和血液的变化。单次剂量600伦琴后造血的自发再生高于该剂量分为两个分次后的再生，但剂量分为两个相等分次的组除外。在接受300 + 300伦琴照射的大鼠组中发现造血再填充最为强烈，该组的初始剂量最小。在分次照射条件下，无论间隔时间多短，第一次剂量对造血系统的再填充能力最为重要。
