通过免疫表面膜标志物特征对儿童急性淋巴细胞白血病（ALL）进行亚型分类（作者译）
[Subtypification of acute lymphocytic leukaemia (ALL) in childhood by characterization of immunological surface membrane markers (author's transl)].
作者信息
Thränhardt H, Milleck J, Zintl F, Schöntube M, Jantscheff P, Plenert W
出版信息
Arch Geschwulstforsch. 1980;50(3):243-52.
Leukaemic blast cells isolated from bone marrow or blood of 42 children with ALL were investigated for presence of immunological surface membrane markers. By characterization of 5 surface markers (reaction with an anti-ALL serum for demonstration of a leukaemia-associated antigen, reaction with an anti-thymocyte serum and formation of E-rosettes for demonstration of T-lymphozytes, as well as reaction with an anti-Ig serum and formation of EAC-rosettes for demonstration of B-lymphocytes) the ALL cells of the 42 patients could be divided into 5 subtypes: I. 18 patients (42,7%( O-ALL with common ALL antigen II. 13 patients (31%) O-ALL without common ALL antigen III. 7 patients (16,7%) T-ALL with E-rosette formation IV. 3 patients (7,2) T-ALL without E-rosette formation V. 1 patients (2,4%) B-ALL.
对从42例急性淋巴细胞白血病（ALL）患儿的骨髓或血液中分离出的白血病原始细胞进行了免疫表面膜标志物检测。通过对5种表面标志物的特征分析（与抗ALL血清反应以证明白血病相关抗原、与抗胸腺细胞血清反应及形成E花环以证明T淋巴细胞，以及与抗Ig血清反应及形成EAC花环以证明B淋巴细胞），42例患者的ALL细胞可分为5个亚型：I. 18例患者（42.7%）：伴有常见ALL抗原的普通型ALL；II. 13例患者（31%）：无常见ALL抗原的普通型ALL；III. 7例患者（16.7%）：形成E花环的T-ALL；IV. 3例患者（7.2%）：未形成E花环的T-ALL；V. 1例患者（2.4%）：B-ALL。
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