Wilson W R, Byl F M, Laird N
Arch Otolaryngol. 1980 Dec;106(12):772-6. doi: 10.1001/archotol.1980.00790360050013.
Double-blind studies were conducted for the treatment of idiopathic sudden hearing loss (ISHL) with oral steroids. The condition was defined as not less than a 30-dB loss over three contiguous frequencies in three days or less. Follow-up audiograms were obtained four weeks and three months later. Specific audiologic guidelines for the assessment of hearing recovery were used to ensure objectivity. Steroids had a statistically significant effect on the recovery of hearing in patients with moderate hearing losses. The nature of the hearing loss and its susceptibility to improvement with steroid therapy lend support to the hypothesis that viral cochlitis is the primary cause of ISHL.
采用口服类固醇对特发性突发性感音神经性听力损失(ISHL)进行了双盲研究。该病症定义为在三天或更短时间内三个连续频率上听力损失不少于30分贝。在四周和三个月后进行了随访听力图检查。使用特定的听力评估指南以确保客观性。类固醇对中度听力损失患者的听力恢复具有统计学上的显著效果。听力损失的性质及其对类固醇治疗改善的易感性支持了病毒性耳蜗炎是ISHL主要病因的假说。