Jearnpipatkul A, Panijpan B
Chem Biol Interact. 1980 Dec;33(1):83-90. doi: 10.1016/0009-2797(80)90045-9.
Chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from Plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin IX and hematoporphyrin. These drugs also compete with one another in their binding to hemin. It is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite.
