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抗疟药物与伯氏疟原虫疟色素的结合

Binding of antimalarial drugs to hemozoin from Plasmodium berghei.

作者信息

Jearnpipatkul A, Govitrapong P, Yuthavong Y, Wilairat P, Panijpan B

出版信息

Experientia. 1980 Sep 15;36(9):1063-4. doi: 10.1007/BF01965970.

DOI:10.1007/BF01965970
PMID:6998717
Abstract

Chloroquine, quinacrine and mefloquine bind to Plasmodium berghei hemozoin, hemin, hemi, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.

摘要

氯喹、阿的平及甲氟喹可与伯氏疟原虫的疟色素、血红素、半血红素、原卟啉IX以及经蛋白酶消化的高铁血红蛋白相结合。这种结合可能是药物在寄生虫体内蓄积及发挥作用的基础。

相似文献

1
Binding of antimalarial drugs to hemozoin from Plasmodium berghei.抗疟药物与伯氏疟原虫疟色素的结合
Experientia. 1980 Sep 15;36(9):1063-4. doi: 10.1007/BF01965970.
2
Molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin.
Chem Biol Interact. 1980 Dec;33(1):83-90. doi: 10.1016/0009-2797(80)90045-9.
3
A common mechanism for blockade of heme polymerization by antimalarial quinolines.抗疟喹啉阻断血红素聚合的常见机制。
J Biol Chem. 1998 Nov 20;273(47):31103-7. doi: 10.1074/jbc.273.47.31103.
4
On the molecular mechanism of chloroquine's antimalarial action.关于氯喹抗疟作用的分子机制
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11865-70. doi: 10.1073/pnas.93.21.11865.
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Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei.谷胱甘肽在耐氯喹伯氏疟原虫中铁卟啉原Ⅸ解毒过程中的作用
Mol Biochem Parasitol. 1999 Jan 25;98(2):215-23. doi: 10.1016/s0166-6851(98)00170-4.
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Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine.疟疾中的氯喹耐药性：药物受体对甲氟喹的可及性
Antimicrob Agents Chemother. 1979 Feb;15(2):258-62. doi: 10.1128/AAC.15.2.258.
7
Depolymerization of malarial hemozoin: a novel reaction initiated by blood schizontocidal antimalarials.疟原虫疟色素的解聚：一种由血液裂殖体杀灭性抗疟药引发的新反应。
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Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs.亚铁原卟啉IX、磷脂与喹啉类药物的抗疟作用
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Quantitative characterization of hemozoin in Plasmodium berghei and vivax.伯氏疟原虫和间日疟原虫中疟色素的定量表征。
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Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait.血红素类似物对恶性疟原虫滋养体提取物中疟色素形成的抑制作用：β-地中海贫血特征赋予疟疾抗性的可能影响。
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引用本文的文献

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Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.恶性疟原虫二氢乳清酸脱氢酶小分子抑制剂的鉴定与表征
J Biol Chem. 2008 Dec 12;283(50):35078-85. doi: 10.1074/jbc.M804990200. Epub 2008 Oct 8.
2
Resistance of Plasmodium falciparum.恶性疟原虫的抗药性
Experientia. 1984 Dec 15;40(12):1311-7. doi: 10.1007/BF01951884.

本文引用的文献

1
ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE.
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2
Hemoglobin synthesis in rabbit reticulocytes in vitro.兔网织红细胞体外血红蛋白的合成
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3
Chloroquine resistance in malaria: a deficiency of chloroquine binding.疟疾中的氯喹耐药性：氯喹结合缺陷
Proc Natl Acad Sci U S A. 1969 Dec;64(4):1181-7. doi: 10.1073/pnas.64.4.1181.
4
Location of chloroquine binding sites in Plasmodium berghei.伯氏疟原虫中氯喹结合位点的定位
Biochem Pharmacol. 1971 Jul;20(7):1619-26. doi: 10.1016/0006-2952(71)90290-5.
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Studies concerning the mechanism of action of antimalarial drugs. II. Inhibition of the incorporation of adenosine-5'-monophosphate- 3 H into nucleic acids of erythrocyte-free malarial parasites.
Biochem Pharmacol. 1971 Jun;20(6):1157-66. doi: 10.1016/0006-2952(71)90346-7.
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Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA.
Nature. 1975 Apr 17;254(5501):632-4. doi: 10.1038/254632a0.
7
Pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in Plasmodium berghei.
Biochem Pharmacol. 1975 Nov 15;24(22):2047-56. doi: 10.1016/0006-2952(75)90101-x.
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Current concepts in parasitology. Malaria.
N Engl J Med. 1977 Dec 8;297(23):1261-4. doi: 10.1056/NEJM197712082972306.
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Plasmodium lophurae: composition and properties of hemozoin, the malarial pigment.鸡疟原虫：疟色素——疟原虫血红蛋白的组成与特性
Exp Parasitol. 1979 Aug;48(1):61-74. doi: 10.1016/0014-4894(79)90055-9.
10
Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine.疟疾中的氯喹耐药性：药物受体对甲氟喹的可及性
Antimicrob Agents Chemother. 1979 Feb;15(2):258-62. doi: 10.1128/AAC.15.2.258.