抗疟药物与伯氏疟原虫疟色素的结合
Binding of antimalarial drugs to hemozoin from Plasmodium berghei.
作者信息
Jearnpipatkul A, Govitrapong P, Yuthavong Y, Wilairat P, Panijpan B
出版信息
Experientia. 1980 Sep 15;36(9):1063-4. doi: 10.1007/BF01965970.
PMID:6998717
Abstract
Chloroquine, quinacrine and mefloquine bind to Plasmodium berghei hemozoin, hemin, hemi, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.
摘要
氯喹、阿的平及甲氟喹可与伯氏疟原虫的疟色素、血红素、半血红素、原卟啉IX以及经蛋白酶消化的高铁血红蛋白相结合。这种结合可能是药物在寄生虫体内蓄积及发挥作用的基础。
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