依前列醇（前列环素，PGI2）对人体脑血流量的影响。
Effect of epoprostenol (prostacyclin, PGI2) on cerebral blood flow in man.
作者信息
Brown M M, Pickles H
出版信息
J Neurol Neurosurg Psychiatry. 1982 Nov;45(11):1033-6. doi: 10.1136/jnnp.45.11.1033.
Abstract
Cerebral blood flow has been measured using the non-invasive Xenon133 clearance technique in eight normal subjects during an infusion of epoprostenol (prostacyclin, PGI2) at a dose of 5 ng/kg/min. The results were compared with a control infusion of saline given in a balanced order. PGI2 was found to result in a reduction in cerebral blood flow of about 8%. PGI2 also caused a small drop in diastolic blood pressure and it is proposed that the fall in cerebral blood flow may have been the result of disturbed autoregulation. The findings suggest that the therapeutic use of PGI2 in patients with cerebral artery spasm would not be accompanied by undesirable intracerebral steal.
摘要
在8名正常受试者以5纳克/千克/分钟的剂量输注依前列醇（前列环素，PGI2）期间，使用非侵入性氙133清除技术测量了脑血流量。将结果与以平衡顺序给予的生理盐水对照输注进行比较。发现PGI2可导致脑血流量减少约8%。PGI2还导致舒张压小幅下降，有人提出脑血流量下降可能是自动调节紊乱的结果。这些发现表明，PGI2在脑动脉痉挛患者中的治疗应用不会伴有不良的脑内窃血现象。
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