吸烟不会减弱依前列醇（前列环素）对人体的心血管作用。
Cigarette smoking does not attenuate the cardiovascular effects of epoprostenol (prostacyclin) in humans.
作者信息
Hassan S, Macdougall I C, O'Grady J, Pickles H
出版信息
Br J Clin Pharmacol. 1982 Jul;14(1):97-8. doi: 10.1111/j.1365-2125.1982.tb04940.x.
Abstract
Infusion of epoprostenol (prostacyclin, PGI) in human subjects leads to a rise in pulse rate, a fall in diastolic pressure and a rise in pulse pressure. In three healthy subjects these responses to PGI were identical before and after 30 min continuous cigarette smoking, and demonstrate that the attenuation of the PGI response by smoking reported in rats does not occur in healthy humans.
摘要
在人体中输注依前列醇（前列环素，PGI）会导致心率上升、舒张压下降以及脉压升高。在三名健康受试者中，连续吸烟30分钟前后，对PGI的这些反应是相同的，这表明在大鼠中所报道的吸烟对PGI反应的减弱在健康人体中并未发生。
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本文引用的文献
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Cigarette smoke inhalation specifically inhibits depressor responses to prostacyclin in the rat.吸入香烟烟雾会特异性抑制大鼠体内对前列环素的降压反应。
Br J Pharmacol. 1981 May;73(1):3-5. doi: 10.1111/j.1476-5381.1981.tb16762.x.
2
Noninvasive assessment of the cardiovascular effects of prostacyclin (PGI2) in man.前列环素（PGI2）对人体心血管作用的无创评估。
Eur J Cardiol. 1980;12(2):73-80.
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