Coulston L, Dandona P
Diabetes. 1980 Aug;29(8):665-7. doi: 10.2337/diab.29.8.665.
In view of the known effect of zinc on the crystalline nature of insulin, we have investigated whether zinc alters the biologic potency of this hormone. Using the rate of lipogenesis by rat epididymal adipocytes as an index of the biologic potency of insulin, we have shown that zinc exerts a potent stimulatory effect upon lipogenesis in vitro similar to, but quite independently of, insulin and that it has an additive effect with that of insulin when both are incubated together. This effect of zinc on adipocytes and the biologic potency of insulin, hitherto unreported, is of significance at the biologic, pharmacologic, and clinical level.
鉴于锌对胰岛素晶体性质的已知作用，我们研究了锌是否会改变这种激素的生物活性。以大鼠附睾脂肪细胞的脂肪生成速率作为胰岛素生物活性的指标，我们发现锌在体外对脂肪生成具有强大的刺激作用，这与胰岛素相似，但完全独立于胰岛素，并且当锌和胰岛素一起孵育时，它与胰岛素具有相加作用。锌对脂肪细胞和胰岛素生物活性的这种作用，迄今尚未见报道，在生物学、药理学和临床层面均具有重要意义。
