Meyer H U, Curchod B, Maeder E, Pahud P, Jequier E, Felber J P
Diabetes. 1980 Sep;29(9):752-6. doi: 10.2337/diab.29.9.752.
A new application of continuous indirect calorimetry is described for measuring the disposal of a glucose load. In a group of 10 normal subjects, 3 h after a 100 g oral glucose load, 20 g glucose was oxidized at basal rate, 19 g in response to the load and 63 g stored, while a decrease of 2 g was observed in the glucose space (GS). In a group of four type I, insulin-dependent diabetics, both glucose oxidation (9 g at the basal rate and 4 g in response to the load) and glucose storage (9 g) were markedly decreased, with the remainder either being lost in the urine (36 g) or remaining in the glucose space (42 g). In a group of eight nonobese type II, non-insulin-dependent diabetics, glucose oxidation both in the basal rate and in response to the load was slightly decreased (13 and 14 g, respectively) and glucose storage decreased to 40 g. These results suggest that, in type I diabetics, complete insulin deficiency seriously impairs two major mechanisms regulating glucose homeostasis, i.e., glucose storage and oxidation, while, in type II diabetics, the remaining insulin secretion attentuates these disturbances.
描述了一种用于测量葡萄糖负荷处置的连续间接测热法的新应用。在一组10名正常受试者中，口服100克葡萄糖负荷3小时后，基础状态下20克葡萄糖被氧化，负荷刺激下19克葡萄糖被氧化，63克葡萄糖被储存，同时葡萄糖空间（GS）减少了2克。在一组4名I型胰岛素依赖型糖尿病患者中，葡萄糖氧化（基础状态下9克，负荷刺激下4克）和葡萄糖储存（9克）均显著降低，其余部分要么经尿液排出（36克），要么留在葡萄糖空间（42克）。在一组8名非肥胖II型非胰岛素依赖型糖尿病患者中，基础状态下和负荷刺激下的葡萄糖氧化均略有降低（分别为13克和14克），葡萄糖储存降至40克。这些结果表明，在I型糖尿病患者中，完全胰岛素缺乏严重损害了调节葡萄糖稳态的两个主要机制，即葡萄糖储存和氧化，而在II型糖尿病患者中，剩余的胰岛素分泌减轻了这些紊乱。
