酿酒酵母中在细胞分裂起始事件中存在缺陷的突变体的筛选。
The selection of S. cerevisiae mutants defective in the start event of cell division.
作者信息
Reed S I
出版信息
Genetics. 1980 Jul;95(3):561-77. doi: 10.1093/genetics/95.3.561.
Abstract
Thirty-three temperature-sensitive mutations defective in the start event of the cell division cycle of Saccharomyces cerevisiae were isolated and subjected to preliminary characterization. Complementation studies assigned thes mutations to four complementation groups, one of which, cdc28, has been described previously. Genetic analysis revealed that these complementation groups define single nuclear genes, unlinked to one another. One of the three newly identified genes, cdc37, has been located in the yeast linkage map on chromosome IV, two meiotic map units distal to hom2.--Each mutation produces stage-specific arrest of cell division at start, the same point where mating pheromone interrupts division. After synchronization at start by incubation at the restrictive temperature, the mutants retain the capacity to enlarge and to conjugate.
摘要
分离出33个在酿酒酵母细胞分裂周期起始事件中存在缺陷的温度敏感突变体，并对其进行了初步表征。互补研究将这些突变体分为四个互补组，其中一个组cdc28，此前已有描述。遗传分析表明，这些互补组定义了单个核基因，它们相互不连锁。三个新鉴定的基因之一，cdc37，已定位在酵母染色体IV的连锁图谱上，位于hom2远端两个减数分裂图谱单位处。——每个突变体在起始点产生细胞分裂的阶段特异性停滞，这与交配信息素中断分裂的点相同。在限制温度下孵育使细胞在起始点同步后，突变体仍保留扩大和接合的能力。
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本文引用的文献
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The selection of amber mutations in genes required for completion of start, the controlling event of the cell division cycle of S. cerevisiae.在酿酒酵母细胞分裂周期的控制事件——起始完成所需基因中琥珀突变的选择。
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