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1
Biosynthesis of the K99 surface antigen is repressed by alanine.K99表面抗原的生物合成受到丙氨酸的抑制。
Infect Immun. 1980 Oct;30(1):125-8. doi: 10.1128/iai.30.1.125-128.1980.
2
Inhibition of K99 antigen synthesis by L-alanine enterotoxigenic Escherichia coli.L-丙氨酸产肠毒素大肠杆菌对K99抗原合成的抑制作用。
J Gen Microbiol. 1982 Mar;128(3):463-70. doi: 10.1099/00221287-128-3-463.
3
Production of K99 antigen by enterotoxigenic Escherichia coli strains of antigen groups o8, o9, o20, and o101 grown at different conditions.抗原组o8、o9、o20和o101的产肠毒素大肠杆菌菌株在不同条件下生长时K99抗原的产生情况。
Infect Immun. 1980 Jan;27(1):216-21. doi: 10.1128/iai.27.1.216-221.1980.
4
Effect of glucose and amino acids on expression of K99 antigen in Escherichia coli.
J Gen Microbiol. 1982 Oct;128(10):2243-9. doi: 10.1099/00221287-128-10-2243.
5
Expression of K99 pilus of E. coli.
Ann Rech Vet. 1983;14(4):400-7.
6
Phenotypic expression of K88 adhesion alone or simultaneously with K99 and/or F41 adhesins in the bovine enterotoxigenic Escherichia coli strain B41.牛产肠毒素大肠杆菌菌株B41中K88黏附素单独或与K99和/或F41黏附素同时存在时的表型表达
Vet Microbiol. 1998 Jan 31;59(4):283-94. doi: 10.1016/s0378-1135(97)00186-7.
7
K99 surface antigen of Escherichia coli: antigenic characterization.大肠杆菌K99表面抗原：抗原特性分析
Infect Immun. 1978 Nov;22(2):555-9. doi: 10.1128/iai.22.2.555-559.1978.
8
Regulation of expression of Escherichia coli pilus K99.大肠杆菌K99菌毛表达的调控
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9
[Selective citrate-adonitol medium for the isolation of various strains of Escherichia coli K99].用于分离多种大肠杆菌K99菌株的选择性柠檬酸盐-阿东醇培养基
Ann Microbiol (Paris). 1984 Jul-Aug;135B(1):29-33.
10
Detection of the K99 antigen by means of agglutination and immunoelectrophoresis in Escherichia coli isolates from calves and its correlation with entertoxigenicity.通过凝集试验和免疫电泳检测犊牛源大肠杆菌分离株中的K99抗原及其与产肠毒素性的相关性。
Infect Immun. 1976 May;13(5):1369-77. doi: 10.1128/iai.13.5.1369-1377.1976.

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Leucine-responsive regulatory protein-mediated repression of clp (encoding CS31A) expression by L-leucine and L-alanine in Escherichia coli.在大肠杆菌中，亮氨酸反应调节蛋白介导L-亮氨酸和L-丙氨酸对clp（编码CS31A）表达的抑制作用。
J Bacteriol. 2003 Mar;185(6):1886-94. doi: 10.1128/JB.185.6.1886-1894.2003.
3
The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.亮氨酸响应调节蛋白，大肠杆菌新陈代谢的全局调节因子。
Microbiol Rev. 1994 Sep;58(3):466-90. doi: 10.1128/mr.58.3.466-490.1994.
4
Expression of the gene cluster associated with the Escherichia coli pilus adhesin K99.与大肠杆菌菌毛黏附素K99相关的基因簇的表达
Infect Immun. 1995 Oct;63(10):4143-9. doi: 10.1128/iai.63.10.4143-4149.1995.
5
Purification, characterization, and partial covalent structure of Escherichia coli adhesive antigen K99.大肠杆菌黏附性抗原K99的纯化、特性鉴定及部分共价结构
Infect Immun. 1981 Sep;33(3):877-83. doi: 10.1128/iai.33.3.877-883.1981.
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The immunogenicity of K99 antigen in whole cell bacterins of Escherichia coli.大肠杆菌全菌疫苗中K99抗原的免疫原性。
Can J Comp Med. 1982 Oct;46(4):426-9.
7
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Infect Immun. 1984 Feb;43(2):508-14. doi: 10.1128/iai.43.2.508-514.1984.
8
Effect of sodium acetate on expression of K99 pili by Escherichia coli.乙酸钠对大肠杆菌K99菌毛表达的影响。
Infect Immun. 1983 Sep;41(3):1368-9. doi: 10.1128/iai.41.3.1368-1369.1983.
9
Regulation of expression of Escherichia coli pilus K99.大肠杆菌K99菌毛表达的调控
Infect Immun. 1983 May;40(2):633-9. doi: 10.1128/iai.40.2.633-639.1983.
10
Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains.非侵袭性产肠毒素大肠杆菌菌株的宿主特异性菌毛黏附素。
Microbiol Rev. 1982 Jun;46(2):129-61. doi: 10.1128/mr.46.2.129-161.1982.

本文引用的文献

1
Production of K99 antigen by enterotoxigenic Escherichia coli strains of antigen groups o8, o9, o20, and o101 grown at different conditions.抗原组o8、o9、o20和o101的产肠毒素大肠杆菌菌株在不同条件下生长时K99抗原的产生情况。
Infect Immun. 1980 Jan;27(1):216-21. doi: 10.1128/iai.27.1.216-221.1980.
2
Cloning and expression of a deoxyribonucleic acid fragment that encodes for the adhesive antigen K99.编码粘附抗原K99的脱氧核糖核酸片段的克隆与表达。
Infect Immun. 1980 Sep;29(3):1125-33. doi: 10.1128/iai.29.3.1125-1133.1980.
3
The isolation of IgG from mammalian sera with the aid of caprylic acid.借助辛酸从哺乳动物血清中分离免疫球蛋白G
Arch Biochem Biophys. 1969 Nov;134(2):279-84. doi: 10.1016/0003-9861(69)90285-9.
4
Further observations on Escherichia coli enterotoxins with particular regard to those produced by atypical piglet strains and by calf and lamb strains: the transmissible nature of these enterotoxins and of a K antigen possessed by calf and lamb strains.关于大肠杆菌肠毒素的进一步观察，特别是关于非典型仔猪菌株以及犊牛和羔羊菌株所产生的肠毒素：这些肠毒素以及犊牛和羔羊菌株所具有的一种K抗原的可传播性质。
J Med Microbiol. 1972 May;5(2):243-50. doi: 10.1099/00222615-5-2-243.
5
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.一种使用显色头孢菌素底物检测β-内酰胺酶的新方法。
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8. doi: 10.1128/AAC.1.4.283.
6
The establishment of K99, a thermolabile, transmissible escherichia coli K antigen, previously called "Kco", possessed by calf and lamb enteropathogenic strains.K99的建立，K99是一种不耐热、可传播的大肠杆菌K抗原，以前称为“Kco”，由牛犊和羔羊肠道致病菌株携带。
Acta Pathol Microbiol Scand B. 1975 Feb;83(1):31-6. doi: 10.1111/j.1699-0463.1975.tb00066.x.
7
Haemagglutinating and adhesive properties associated with the K99 antigen of bovine strains of Escherichia coli.与大肠杆菌牛源菌株K99抗原相关的血凝和黏附特性。
J Gen Microbiol. 1976 Oct;96(2):269-75. doi: 10.1099/00221287-96-2-269.
8
Detection of the K99 antigen by means of agglutination and immunoelectrophoresis in Escherichia coli isolates from calves and its correlation with entertoxigenicity.通过凝集试验和免疫电泳检测犊牛源大肠杆菌分离株中的K99抗原及其与产肠毒素性的相关性。
Infect Immun. 1976 May;13(5):1369-77. doi: 10.1128/iai.13.5.1369-1377.1976.
9
Cloning, mapping and expression of the genetic determinant that encodes for the K88ab antigen.
Nucleic Acids Res. 1979 Mar;6(3):849-65. doi: 10.1093/nar/6.3.849.
10
Serology, chemistry, and genetics of O and K antigens of Escherichia coli.大肠杆菌O抗原和K抗原的血清学、化学及遗传学
Bacteriol Rev. 1977 Sep;41(3):667-710. doi: 10.1128/br.41.3.667-710.1977.

K99表面抗原的生物合成受到丙氨酸的抑制。

Biosynthesis of the K99 surface antigen is repressed by alanine.

作者信息

de Graaf F K, Klaasen-Boor P, van Hees J E

出版信息

Infect Immun. 1980 Oct;30(1):125-8. doi: 10.1128/iai.30.1.125-128.1980.

DOI:10.1128/iai.30.1.125-128.1980
PMID:7002786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551285/
Abstract

The amino acid alanine induced a direct and specific repression of the biosynthesis of the K99 surface antigen in Escherichia coli strains harboring the K99 plasmid. In minimal medium with 0.5% glucose, 1 mM L-alanine was sufficient to reduce the K99 production by about 95%. The low production of the K99 antigen by strains growing on commercially available nutrient media seemed to be a result of the inhibitory effect alanine on the K99 biosynthesis.

摘要

氨基酸丙氨酸可直接特异性抑制携带K99质粒的大肠杆菌菌株中K99表面抗原的生物合成。在含有0.5%葡萄糖的基本培养基中，1 mM L-丙氨酸足以使K99的产量降低约95%。在市售营养培养基上生长的菌株中K99抗原产量较低，这似乎是丙氨酸对K99生物合成的抑制作用所致。