外膜蛋白的过量产生抑制envA诱导的高通透性。
Overproduction of outer membrane protein suppresses envA-induced hyperpermeability.
作者信息
Grundström T, Normark S, Magnusson K E
出版信息
J Bacteriol. 1980 Dec;144(3):884-90. doi: 10.1128/jb.144.3.884-890.1980.
Abstract
A quantitative study on outer membrane components was performed in a number of envelope mutants of Escherichia coli K-12 exhibition different permeability properties for antimicrobial agents. The envA1 allele causing an increased influx for both hydrophobic and hydrophilic drugs was found to be associated with a deficiency in the amount of lipopolysaccharides. The sefA1 envA1 double mutant was found to have a higher outer membrane buoyant density, apparently due to an increase in protein content. This double mutant was still low in lipopolysaccharide content.
摘要
对大肠杆菌K-12的一些包膜突变体进行了外膜成分的定量研究，这些突变体对抗菌剂表现出不同的通透性。发现导致疏水性和亲水性药物流入增加的envA1等位基因与脂多糖含量不足有关。发现sefA1 envA1双突变体具有更高的外膜浮力密度，这显然是由于蛋白质含量增加所致。该双突变体的脂多糖含量仍然很低。
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