Mazet F, Ehrhart J C
J Physiol (Paris). 1980 Nov;76(6):529-49.
Some structural features of the different types of intercellular junctions which occur in vertebrate tissues (desmosomes, tight and gap junctions, Table 1) are first mentioned. Then, this review is exclusively concerned with gap junctions. The ubiquitous occurrence of these junctions throughout the phylogenetic scale up to man points to a major functional role. Cells of most organized tissues make cell-to-cell channels, 1-2 nm diameter, that provide a structural hydrophilic pathway for free diffusion of inorganic ions and small molecules. Ionic coupling and metabolic cooperation have been shown to be functional expressions of the direct intercellular communication. The role of gap junctions in nonexcitable tissues is not well established (Chap. III). While these junctions are clearly involved in the regulation of some enzymatic activities and exocrine and endocrine secretions, the cell-to-cell transmission of signal molecules necessary for growth control remains largely hypothetical.
首先提及脊椎动物组织中出现的不同类型细胞间连接（桥粒、紧密连接和缝隙连接，见表1）的一些结构特征。然后，本综述专门关注缝隙连接。这些连接在整个系统发育尺度直至人类中普遍存在，这表明其具有重要的功能作用。大多数有组织的组织细胞形成直径为1 - 2纳米的细胞间通道，为无机离子和小分子的自由扩散提供了一条亲水性结构途径。离子偶联和代谢合作已被证明是直接细胞间通讯的功能表现。缝隙连接在非兴奋性组织中的作用尚未明确（第三章）。虽然这些连接显然参与了一些酶活性以及外分泌和内分泌分泌的调节，但生长控制所需信号分子的细胞间传递在很大程度上仍只是假设。
