马来西亚沙巴州恶性疟原虫对4-氨基喹啉类（氯喹）耐药性的研究。
Study of Plasmodium falciparum resistance to 4-Aminoquinolines (Chloroquine) in Sabah, Malaysia.
作者信息
Maqsudur Rahman K M
出版信息
J Trop Med Hyg. 1980 Dec;83(6):259-64.
The status of P. falciparum resistance to chloroquine in Sabah, Malaysia were not know until 1971-1972. Several in-vivo and on in-vivo studies were conducted from 971-1975, and the result showed 51% out of total 57 cases studied were resistant to chloroquine. The latest in-vitro study (collaborative with WHO) started in July 1978, to continue till 1980, to cover the whole State. The preliminary result shows 65 cases (85%) out of a total 76 successful tests are resistant to chloroquine. On the basis of this preliminary result, the radical treatment for P. falciparum infection was changed from chloroquine to Fansidar from June 1979 throughout the State.
直到1971 - 1972年，马来西亚沙巴州恶性疟原虫对氯喹的抗药性状况才为人所知。1971年至1975年进行了多项体内和体外研究，结果显示，在总共研究的57例病例中，有51%对氯喹耐药。最新的体外研究（与世界卫生组织合作）于1978年7月开始，持续到1980年，覆盖整个州。初步结果显示，在总共76次成功检测的病例中，有65例（85%）对氯喹耐药。基于这一初步结果，从1979年6月起，全州针对恶性疟原虫感染的根治性治疗从氯喹改为 Fansidar。
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