苯丙氨酸转运核糖核酸的静电分子势。IV. 与碱基相关位点的势和空间可及性
The electrostatic molecular potential of tRNAPhe. IV. The potentials and steric accessibilities of sites associated with the bases.
作者信息
Lavery R, Pullman A, Pullman B, de Oliveira M
出版信息
Nucleic Acids Res. 1980 Nov 11;8(21):5095-111. doi: 10.1093/nar/8.21.5095.
Abstract
The sites of the 76 nucleic acid bases of tRNAPhe potentially reactive towards electrophiles are studied by calculations on the associated molecular electrostatic potentials and the static steric accessibilities. Each of these sites is treated in its environment within the macromolecule. The influence of various schemes of screening by countercations of the backbone phosphates on the electrostatic potentials is investigated. The possible significance of the potentials and accessibilities in connection with observed chemical reactivities is discussed.
摘要
通过对相关分子静电势和静态空间可及性的计算，研究了苯丙氨酸转运核糖核酸（tRNAPhe）76个核酸碱基中可能对亲电试剂有反应的位点。这些位点中的每一个都在大分子内其所处环境中进行处理。研究了主链磷酸根抗衡阳离子的各种屏蔽方案对静电势的影响。讨论了这些势和可及性与观察到的化学反应性相关的可能意义。
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本文引用的文献
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