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[骨移植治疗血源性骨髓炎]

[Bone grafting in the treatment of hematogenic osteomyelitis].

作者信息

Popkirov S

出版信息

Probl Khig. 1980;8:9-26.

PMID:7003589
Abstract

A qualitatively new method is introduced, developed and established in practice on the ground of clinical experience with 44 patients with hematogenic osteomyelitis. Thus the idea about "osteoplastic treatment of osteomyelitis" is adopted. Bone transplantation is the basic and dynamic factor of this type of management. Contrary to traditional concepts the author's clinical experience shows that successful bone grafting is possible provided all specific requirements are met, namely radical removal of the purulent-necrotic substrate, presence of regeneration potential in the recipient bed, creation of favourable conditions for wound healing by first intention, and active struggle against infection as a permanently acting factor, and in case it is already present. The bone transplant in addition to promoting elimination of the osteomyelitic bone defect, which is the primary pathogenic factor of chronic pus discharge, contributes also to the cure of the basic process in the course of its dynamic interaction with the recipient bone. Bone auto-, allo- and xeno (calf)-grafts are used as transplantation material. The indications for osteoplastic treatment, the surgical policy, operative technique and operative procedures are presented. The proposed original operative methods of osteoplastic management are submitted schematically and illustrated by single case reports. Complete cure as the result of osteoplastic treatment alone is attained in 388 cases or 87.3 per cent out of the total number of 444 patients. In the remaining 55 cases in whom the treatment failed, reoperation was performed because of residual foci, complications on behalf of the graft (sequestration), persistent fistulae or skin defects, resulting in the cure of fifty of them. Here too, the attained result is attributable to the osteoplastic treatment. Hence out of the total number of 444 patients operated on a cure is achieved in 434 cases or 97.7 per cent. After comparative evaluation of the quality of bone graft a net preference is given to cancellous autografts. A transplant taken from the iliac crest is considered as the optimal quality one. Regarding massive bone grafts, auto- or allogenous alike, a rather elevated sequestration rate is recorded, 10 and 33 per cent respectively. A particular importance is ascribed to the regenerative qualities of the recipient bed. Results recorded among children are superior. In patients free of fistulae the rate of cures is 19.3 per cent higher in patients with fistulae.

摘要

基于对44例血源性骨髓炎患者的临床经验,一种全新的方法得以引入、发展并在实践中确立。由此采用了“骨髓炎的骨成形治疗”这一理念。骨移植是此类治疗的基本且关键因素。与传统观念相反,作者的临床经验表明,只要满足所有特定要求,成功进行骨移植是可行的,这些要求包括彻底清除脓性坏死组织、受植床具备再生潜能、为一期愈合创造有利的伤口愈合条件,以及作为持续作用因素积极对抗感染(若感染已经存在)。骨移植除了有助于消除骨髓炎骨缺损(慢性脓液排出的主要致病因素)外,在与受植骨的动态相互作用过程中,也有助于治愈基本病程。自体骨、同种异体骨和异种(小牛)骨移植均用作移植材料。文中介绍了骨成形治疗的适应证、手术策略、手术技术和手术步骤。所提出的骨成形治疗的原创手术方法以示意图形式呈现,并通过单病例报告加以说明。在444例患者中,仅通过骨成形治疗就实现完全治愈的有388例,占总数的87.3%。在其余55例治疗失败的病例中,因残留病灶、移植相关并发症(死骨形成)、持续性瘘管或皮肤缺损而进行了再次手术,其中50例得以治愈。在此,所取得的结果同样归因于骨成形治疗。因此,在接受手术的444例患者中,共有434例治愈,治愈率为97.7%。在对骨移植质量进行比较评估后,明显更倾向于使用松质骨自体移植。取自髂嵴的移植骨被认为质量最佳。对于大块骨移植,无论是自体骨还是同种异体骨,死骨形成率都相当高,分别为10%和33%。受植床的再生特性被赋予了特别重要的意义。儿童患者的治疗结果更佳。无瘘管患者的治愈率比有瘘管患者高19.3%。

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